Web of Science: 4 cites, Scopus: 4 cites, Google Scholar: cites,
Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder
Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sanvisens, Arantza (Girona Biomedical Research Institute. Clinical Pharmacology Department)
Barbier-Torres, Lucía (Cedars-Sinai Medical Center)
Blanes, Rafael (Hospital Universitari Son Dureta (Palma de Mallorca, Balears))
Miquel, Laia (Universitat de Barcelona)
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) [...] Mostra tots els 14 autors

Data: 2023
Descripció: 7 pàg.
Resum: INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD. PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission. RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11. 2%, higher than that observed for hypocalcemia (9. 3%), hyponatremia (5. 6%), and hypokalemia (2. 8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3. 25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8. 91; 95% CI, 3. 3-23. 9) and eGFR < 60 mL (OR, 5. 2; 95% CI, 1. 0-26. 2) were the only factors associated with hypoMg. CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
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Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Alcohol use disorder ; Electrolyte disturbances ; Magnesium deficiency ; Oxidative stress ; Liver Cirrhosis/complications ; Cross-Sectional Studies ; Humans ; Middle Aged ; Male ; Alcohol Drinking ; Alcoholism/epidemiology ; Adult ; Female ; Magnesium ; SDG 3 - Good Health and Well-being

DOI: 10.1016/j.drugalcdep.2023.109822
PMID: 36893509


7 p, 638.1 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2024-02-03, darrera modificació el 2024-10-09



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