Adaptation of the hypothalamus-pituitary-adrenal axis to daily repeated stress does not follow the rules of habituation : A new perspective
Rabasa, Cristina (Institute of Neuroscience and Physiology. The Sahlgrenska Academy at University of Gothenburg (Suècia))
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pastor-Ciurana, Jordi (Red Temática de Investigación Cooperativa en Salud (RETICS-Trastornos Adictivos))
Fuentes, Silvia (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Belda, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2015
Abstract:	Repeated exposure to a wide range of stressors differing in nature and intensity results in a reduced response of prototypical stress markers (i. e. plasma levels of ACTH and adrenaline) after an acute challenge with the same (homotypic) stressor. This reduction has been considered to be a habituation-like phenomenon. However, direct experimental evidence for this assumption is scarce. In the present work we demonstrate in adult male rats that adaptation of the hypothalamus-pituitary-adrenal (HPA) axis to repeated stress does not follow some of the critical rules of habituation. Briefly, adaptation was stronger and faster with more severe stressors, maximally observed even with a single exposure to severe stressors, extremely long-lasting, negatively related to the interval between the exposures and positively related to the length of daily exposure. We offer a new theoretical view to explain adaptation to daily repeated stress.
Grants:	Ministerio de Economía y Competitividad SAF2011-28313 Ministerio de Economía y Competitividad RD12/0028/0014 Ministerio de Ciencia e Innovación PTA2010-3472-I Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1020
Note:	Altres ajuts: Plan Nacional sobre Drogas (2011/021)
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió acceptada per publicar
Subject:	Habituation ; Repeated Stress ; Immobilization ; Restraint ; Water stress ; ACTH ; Corticosterone ; C-fos
Published in:	Neuroscience & biobehavioral reviews, Vol. 56 (september 2015) , p. 35-49, ISSN 1873-7528

DOI: 10.1016/j.neubiorev.2015.06.013

43 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles