Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer : Supporting personalised screening
Román, M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Quintana Ruiz, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau)
Ferrer, J. (Parc Hospitalari Martí i Julià)
Sala, M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Castells, X. (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of breast cancer. The cohort included 42 928 women first screened at the age of 50-51 years at three areas of the Spanish Screening Programme (Girona, and two areas in Barcelona) between 1996 and 2011, and followed up until December 2012. We used discrete-time survival models to estimate the cumulative risk of each screening outcome over 10 biennial screening exams. The cumulative risk of false-positive results, screen-detected breast cancer, and interval cancer was 36. 6, 5. 3, and 1. 4 for women with a previous benign breast disease, 24. 1, 6. 8, and 1. 6% for women with a family history of breast cancer, 37. 9, 9. 0, and 3. 2%; for women with both a previous benign breast disease and a family history, and 23. 1, 3. 2, and 0. 9% for women without either of these antecedents, respectively. Women with a benign breast disease or a family history of breast cancer had an increased cumulative risk of favourable and unfavourable screening outcomes than women without these characteristics. A family history of breast cancer did not increase the cumulative risk of false-positive results. Identifying different risk profiles among screening participants provides useful information to stratify women according to their individualised risk when personalised screening strategies are discussed.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Benign breast disease ; Breast neoplasms ; False positive ; Family history ; Interval cancer ; Mammography screening ; Personalised screening
Published in:	British journal of cancer, Vol. 116 Núm. 11 (23 2017) , p. 1480-1485, ISSN 1532-1827

DOI: 10.1038/bjc.2017.107
PMID: 28427083

6 p, 255.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles