Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies
Pasquini, Marcelo (Medical College of Wisconsin)
Zhang, Mei-Jie (Medical College of Wisconsin)
Medeiros, Bruno (Stanford University School of Medicine)
Armand, Philippe (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica))
Hu, Zhen-Huan (Medical College of Wisconsin)
Nishihori, Taiga (H. Lee Moffitt Cancer Center and Research Institute)
Aljurf, Mahmoud D. (King Faisal Specialist Hospital Center and Research)
Akpek, Görgün (Banner MD Anderson Cancer Center)
Cahn, Jean-Yves (University Hospital)
Cairo, Mitchell S. (New York Medical College)
Cerny, Jan (UMass Memorial Medical Center)
Copelan, Edward A. (Carolinas HealthCare System)
Deol, Abhinav (Wayne State University)
Freytes, César O. (University of Texas Health Science Center San Antonio)
Gale, Robert Peter (Imperial College London)
Ganguly, Siddhartha (University of Kansas Medical Center)
George, Biju (Christian Medical College)
Gupta, Vikas (University Health Network)
Hale, Gregory A. (All Children's Hospital)
Kamble, Rammurti T. (Baylor College of Medicine)
Klumpp, Thomas R. (Thomas Jefferson University Hospital)
Lazarus, Hillard M. (University Hospitals Case Medical Center)
Luger, Selina M. (University of Pennsylvania Medical Center)
Liesveld, Jane L. (University of Rochester Medical Center)
Litzow, Mark Robert (Mayo Clinic)
Marks, David I. (University Hospitals Bristol NHS Trust)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Norkin, Maxim (University of Florida College of Medicine)
Olsson, Richard F. (Uppsala University)
Oran, Betul (The University of Texas MD Anderson Cancer Center)
Pawarode, Attaphol (University of Michigan)
Pulsipher, Michael A. (University of Southern California Keck School of Medicine)
Ramanathan, Muthalagu (UMass Memorial Medical Center)
Reshef, Ran (University of Pennsylvania Medical Center)
Saad, Ayman A. (University of Alabama at Birmingham)
Saber, Wael (Medical College of Wisconsin)
Savani, Bipin N. (Vanderbilt University Medical Center)
Schouten, Harry C. (Academische Ziekenhuis)
Ringdén, Olle (Centre for Allogeneic Stem Cell Transplantation)
Tallman, Martin S. (Memorial Sloan Kettering Cancer Center)
Uy, Geoffrey L. (Washington University School of Medicine)
Wood, William A. (University of North Carolina)
Wirk, Baldeep (Seattle Cancer Care Alliance)
Pérez, Waleska S. (Medical College of Wisconsin)
Batiwalla, Minoo (National Heart Lung and Blood Institute - National Institutes of Health)
Weisdorf, Daniel J. (University of Minnesota Medical Center)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	The presence of monosomal karyotype (MK+) in acute myeloid leukemia (AML) is associated with dismal outcomes. We evaluated the impact of MK+ in AML (MK+AML, n = 240) and in myelodysplastic syndrome (MDS) (MK+MDS, n = 221) on hematopoietic cell transplantation outcomes compared with other cytogenetically defined groups (AML, n = 3360; MDS, n = 1373) as reported to the Center for International Blood and Marrow Transplant Research from 1998 to 2011. MK+ AML was associated with higher disease relapse (hazard ratio, 1. 98; P <. 01), similar transplantation-related mortality (TRM) (hazard ratio, 1. 01; P =90), and worse survival (hazard ratio, 1. 67; P <. 01) compared with those outcomes for other cytogenetically defined AML. Among patients with MDS, MK+ MDS was associated with higher disease relapse (hazard ratio, 2. 39; P <. 01), higher TRM (hazard ratio, 1. 80; P <. 01), and worse survival (HR, 2. 02; P <. 01). Subset analyses comparing chromosome 7 abnormalities (del7/7q) with or without MK+ demonstrated higher mortality for MK+ disease in for both AML (hazard ratio, 1. 72; P <. 01) and MDS (hazard ratio, 1. 79; P <. 01). The strong negative impact of MK+ in myeloid malignancies was observed in all age groups and using either myeloablative or reduced-intensity conditioning regimens. Alternative approaches to mitigate disease relapse in this population are needed.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Acute myeloid leukemia ; Allogeneic transplantation ; Monosomal karyotype ; Myelodysplastic syndrome
Published in:	Biology of blood and marrow transplantation, Vol. 22 Núm. 2 (january 2016) , p. 248-257, ISSN 1523-6536

DOI: 10.1016/j.bbmt.2015.08.024
PMID: 26327629

34 p, 950.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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