RIC versus MAC UCBT in adults with AML : A report from Eurocord, the ALWP and the CTIWP of the EBMT
Baron, Frédéric (University of Liege)
Ruggeri, Annalisa (Hôpital Saint-Antoine (Paris, França))
Beohou, Eric (Hôpital Saint-Antoine (Paris, França))
Labopin, Myriam (Hôpital Saint-Antoine (Paris, França))
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València))
Milpied, Noel (University of Bordeaux)
Michallet, Mauricette (Centre Hospitalier de Lyon Sud)
Bacigalupo, Andrea (Ospedale San Martino)
Blaise, Didier (Aix-Marseille Université)
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau)
Socié, Gérard (Hospital Saint-Louis)
Cornelissen, Jan J. (Erasmus Medical Center-Daniel den Hoed Cancer Center)
Schmid, Christoph (University of Munich)
Giebel, Sebastian (Gliwice Branch)
Gorin, Norbert-Claude (Hospital Saint Antoine)
Esteve, Jordi (Hematology. Hospital Clinic)
Ciceri, Fabio (Ospedale San Raffaele)
Savani, Bipin N. (Vanderbilt University Medical Center)
Mohty, Mohamad (UMRs 938)
Gluckman, Eliane (Centre Scientifique de Monaco)
Nagler, Arnon (The Chaim Sheba Medical Center)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Nonrelapse mortality (NRM) is the first cause of treatment failure after unrelated cord blood transplantation (UCBT) following myeloablative conditioning (MAC). In the last decade, reduced-intensity conditioning (RIC) regimens have been developed with the aim of reducing NRM and allowing older patients and those with medical comorbidities to benefit from UCBT. The aim of the current retrospective study was to compare transplantation outcomes of acute myeloid leukemia (AML) patients given UCBT after either RIC or MAC. Data from 894 adults with AML receiving a single or double UCBT as first allograft from 2004 to 2013 at EBMT centers were included in this study. 415 patients were given UCBT after RIC while 479 patients following a MAC. In comparison to MAC recipients, RIC recipients had a similar incidence of neutrophil engraftment and of acute and chronic graft-versus-host disease (GVHD). However, RIC recipients had a higher incidence of disease relapse and a lower NRM, translating to comparable leukemia-free (LFS), GVHD-free, relapse-free survival (GRFS) and overall survival (OS). These observations remained qualitatively similar after adjusting for differences between groups in multivariate analyses. In conclusion, these data suggest that LFS and OS are similar with RIC or with MAC in adults AML patients transplanted with UCBT. These observations could serve as basis for a future prospective randomized study.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	AML ; Myeloablative ; Reduced-intensity ; Transplantation ; Unrelated cord blood
Published in:	Oncotarget, Vol. 7 Núm. 28 (2016) , p. 43027-43038, ISSN 1949-2553

DOI: 10.18632/oncotarget.9599
PMID: 27250025

12 p, 804.5 KB

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Articles > Research articles
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