Opportunistic genetic screening increases the diagnostic yield and is medically valuable for care of patients and their relatives with hereditary cancer
Fernández-Castillejo, Sara (Universitat Rovira i Virgili)
Roig, Bàrbara (Universitat Rovira i Virgili)
Melé, Mireia (Universitat Rovira i Virgili)
Serrano, Sara (Universitat Rovira i Virgili)
Salvat, Mònica (Universitat Rovira i Virgili)
Querol, Montserrat (Universitat Rovira i Virgili)
Brunet, Joan (Institut d'Investigació Biomèdica de Bellvitge)
Pineda, Marta (Institut d'Investigació Biomèdica de Bellvitge)
Cisneros, Adela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Parada, David (Institut d'Investigació Sanitària Pere Virgili)
Badia, Joan (Universitat Rovira i Virgili)
Borràs, Joan (Universitat Rovira i Virgili)
Rodríguez-Balada, Marta (Universitat Rovira i Virgili)
Gumà, Josep (Universitat Rovira i Virgili)

Data:	2023
Resum:	Background: Multigene panel testing by next-generation sequencing (MGP-NGS) enables the detection of germline pathogenic or likely pathogenic variants (PVs/LPVs) in genes beyond those associated with a certain cancer phenotype. Opportunistic genetic screening based on MGP-NGS in patients with suspicion of hereditary cancer reveals these incidental findings (IFs). Methods: MGP-NGS was performed in patients who fulfilled the clinical criteria to undergo genetic testing according to the Catalan Health Service guidelines. Variants were classified following the American College of Medical Genetics and Genomics-Association for Molecular Pathology guidelines and the Cancer Variant Interpretation Group UK guidelines. Results: IFs were identified in 10 (1. 22%) of the 817 patients who underwent MGP-NGS. The mean age at cancer diagnosis was 49. 4±9. 5 years. Three IFs (30. 0%) were detected in PMS2, two (20. 0%) in ATM and TP53 and one (10. 0%) in MSH6, NTHL1 and VHL. Seven (70. 0%) IFs were single-nucleotide substitutions, two (20. 0%) were deletions and one (10. 0%) was a duplication. Three (30. 0) IFs were located in intronic regions, three (30. 3%) were nonsense, two (20. 0%) were frameshift and two (20. 0%) were missense variations. Six (60. 0%) IFs were classified as PVs and four (40. 0%) as LPVs. Conclusions: Opportunistic genetic screening increased the diagnostic yield by 1. 22% in our cohort. Most of the identified IFs were present in clinically actionable genes (n=7; 70. 0%), providing these families with an opportunity to join cancer early detection programmes, as well as secondary cancer prevention. IFs might facilitate the diagnosis of asymptomatic individuals and the early management of cancer once it develops.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Journal of medical genetics, Vol. 61, Num. 1 (december 2023) , p. 69-77, ISSN 1468-6244

DOI: 10.1136/jmg-2023-109389
PMID: 37591735

9 p, 406.9 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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