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Página principal > Artículos > Artículos publicados > Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed : |
Fecha: | 2022 |
Resumen: | High-density lipoproteins (HDL) undergo adverse remodeling and loss of function in the presence of comorbidities. We assessed the potential of lipid-lowering approaches (diet and rosuvastatin) to rescue hypercholesterolemia-induced HDL dysfunction. Hypercholesterolemia was induced in 32 pigs for 10 days. Then, they randomly received one of the 30-day interventions: (I) hypercholesterolemic (HC) diet; (II) HC diet + rosuvastatin; (III) normocholesterolemic (NC) diet; (IV) NC diet + rosuvastatin. We determined cholesterol efflux capacity (CEC), antioxidant potential, HDL particle number, HDL apolipoprotein content, LDL oxidation, and lipid levels. Hypercholesterolemia time-dependently impaired HDL function (−62% CEC, −11% antioxidant index (AOI); p < 0. 01), increased HDL particles numbers 2. 8-fold (p < 0. 0001), reduced HDL-bound APOM (−23%; p < 0. 0001), and increased LDL oxidation 1. 7-fold (p < 0. 0001). These parameters remained unchanged in animals on HC diet alone up to day 40, while AOI deteriorated up to day 25 (−30%). The switch to NC diet reversed HDL dysfunction, restored apolipoprotein M content and particle numbers, and normalized cholesterol levels at day 40. Rosuvastatin improved HDL, AOI, and apolipoprotein M content. Apolipoprotein A-I and apolipoprotein C-III remained unchanged. Lowering LDL-C levels with a low-fat diet rescues HDL CEC and antioxidant potential, while the addition of rosuvastatin enhances HDL antioxidant capacity in a pig model of hypercholesterolemia. Both strategies restore HDL-bound apolipoprotein M content. |
Ayudas: | Agencia Estatal de Investigación 2018-094025-B-I00 Agencia Estatal de Investigación PID2019-107160RB-I00 Ministerio de Economía y Competitividad CB16/11/00411 Agencia Estatal de Investigación 2018-094025-B-I00 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | HDL dysfunction ; Diet ; Hypercholesterolemia ; Pig ; Statin |
Publicado en: | International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8596, ISSN 1422-0067 |
17 p, 3.9 MB |