Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis
Suades, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Greco, Maria Francesca (Università degli Studi di Milano)
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality all over the world. Extracellular vesicles (EVs), small lipid-bilayer membrane vesicles released by most cellular types, exert pivotal and multifaceted roles in physiology and disease. Emerging evidence emphasizes the importance of EVs in intercellular communication processes with key effects on cell survival, endothelial homeostasis, inflammation, neoangiogenesis, and thrombosis. This review focuses on EVs as effective signaling molecules able to both derail vascular homeostasis and induce vascular dysfunction, inflammation, plaque progression, and thrombus formation as well as drive anti-inflammation, vascular repair, and atheroprotection. We provide a comprehensive and updated summary of the role of EVs in the development or regression of atherosclerotic lesions, highlighting the link between thrombosis and inflammation. Importantly, we also critically describe their potential clinical use as disease biomarkers or therapeutic agents in atherothrombosis.
Grants:	Agencia Estatal de Investigación PID2019-107160RB-I00 Ministerio de Economía y Competitividad CB16/11/00411 Instituto de Salud Carlos III PI19/01687
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Atherosclerosis ; Atherothrombosis ; Extracellular vesicles ; Immunoinflammation ; Immunothrombosis ; Inflammation ; Microvesicles ; Thromboinflammation ; Thrombosis
Published in:	Cells, Vol. 11 Núm. 11 (6-1 2022) , p. 1845, ISSN 2073-4409

DOI: 10.3390/cells11111845
PMID: 35681540

30 p, 992.5 KB

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