Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy
Barata, Anna (Institut d'Investigació Biomèdica Sant Pau)
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau)
Gutiérrez Hernández, Maria del Mar (Institut d'Investigació Biomèdica Sant Pau)
Mateo, María Gracia (Institut d'Investigació Biomèdica Sant Pau)
Sambeat, Maria Antònia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gich, Ignasi (Institut d'Investigació Biomèdica Sant Pau)
Cadafalch, Josep (Institut d'Investigació Biomèdica Sant Pau)
Wulff, Juan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Domingo, Pere (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	To study whether patients with HIV-1 associated lipodystrophy (LD) on highly active antiretroviral treatment (HAART) have more psychopathology and worse psychosocial adjustment than a similar group without this syndrome. In a cross-sectional, observational study we compared 47 HIV-1 infected patients with LD (LD group) with 39 HIV-1 infected patients without LD (non-LD group). All participants were on HAART. The Beck Depression Inventory (BDI), the State and Trait Anxiety Inventory (STAI) and the Goldberg Health Questionnaire (GHQ-60) were administered. Levels of familial, work and social adjustment and adjustment to stressful events were evaluated in a semi-structured interview. Clinical information was extracted from the clinical records. In the univariate analysis patients with LD showed higher state anxiety scores (p = 0. 009) and worse work adjustment (p = 0. 019) than those without LD. A total of 45. 3% of LD patients scored above the cut-off point on the trait anxiety scale, and over 33. 3% scored above the cut-off point on the BDI, GHQ and state anxiety scales. However, in multivariate analyses LD was not independently associated with psychopathology or with worse adjustment in the studied areas. The finding that LD was not a predictor of greater psychopathology or worse psychosocial adjustment in HIV-1 infected patients, despite the high scores found, suggests that factors not taken into account in this study, such as LD severity and self-perception should have been included in the analysis. Further studies including a greater number of variables and a larger sample size will advance our understanding of this complex condition.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HIV ; Lypodystrophy ; Psychopathology ; Psychosocial
Published in:	The Brazilian Journal of Infectious Diseases, Vol. 17 (june 2013) , p. 444-449, ISSN 1678-4391

DOI: 10.1016/j.bjid.2012.11.011
PMID: 23742804

6 p, 557.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles