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Quantitative Microvascular Change Analysis Using a Semi-Automated Algorithm in Macula-on Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography
Díaz Aljaro, Pablo (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Valldeperas, Xavier (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Broc Iturralde, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Romanic Bubalo, Nevena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Díaz Aljaro, Ignacio (Hospital Clinico Universidad de Chile (Santiago de Xile, Xile))
Chu, Zhongdi (University of Washington. Department of Bioengineering)
Wang, Ruikang K. (University of Washington. Department of Bioengineering)
Zarranz-Ventura, Javier (Hospital Clínic i Provincial de Barcelona)

Fecha: 2024
Resumen: Purpose: The purpose of this study was to objectively evaluate the longitudinal changes observed in the retinal capillaries in eyes with macula-on rhegmatogenous retinal detachment (RRD), assessed with optical coherence tomography angiography (OCTA), and to assess the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: This was a prospective, longitudinal study conducted on consecutive patients who underwent 25 G pars plana vitrectomy for primary RRD. The vessel area density (VAD), vessel skeleton density (VSD), and vessel diameter index (VDI) were assessed in the superficial (SCP) and deep (DCP) capillary plexuses. Results: Twenty-three eyes with macula-on RRD were included in the study. The mean preoperative VDI, VAD, and VSD of the RRD eye were 18. 6 ± 1. 1, 0. 43 ± 0. 02, and 0. 17 ± 0. 01 in the SCP; and 18. 6 ± 0. 6, 0. 38 ± 0. 03, and 0. 15 ± 0. 01 in the DCP, respectively. At month 6, eight (34. 8%) eyes achieved a best-corrected visual acuity (BCVA) gain ≥ 0. 1 LogMAR. A preoperative VDI > 17. 80, VSD > 0. 170, and VDI-change > −0. 395 in the SCP; and VDI > 18. 11 and VDI change > −0. 039 in the DCP were predictors of achieving a BCVA-gain ≥ 0. 1 LogMAR. Conclusions: The preoperative VDI in SCP and DCP, the preoperative VSD in SCP, and their changes from preoperative values were predictors of visual outcomes. A quantitative OCTA analysis of capillary density and morphology may represent a potential predictive tool for surgical outcomes in RRD. The results reported in this study suggest that OCTA is a useful ancillary test for clinical disease management.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: Article ; recerca ; Versió publicada
Materia: Rhegmatogenous retinal detachment ; Microvascular changes ; Optical coherence tomography angiography
Publicado en: Diagnostics, Vol. 14 (april 2024) , ISSN 2075-4418

DOI: 10.3390/diagnostics14070750
PMID: 38611663


15 p, 3.3 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2024-04-24, última modificación el 2024-05-14



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