Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment
Vázquez-de Sebastián, Julia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ortiz Zúñiga, Ángel Michael (Hospital Universitari Vall d'Hebron)
Ciudin, Andreea (Hospital Universitari Vall d'Hebron)
Ars, Joan (Universitat Autònoma de Barcelona. Departament de Medicina)
Inzitari, Marco (Universitat Oberta de Catalunya. Facultat de Ciències de la Salut)
Simó Canonge, Rafael (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Hernández, Cristina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Ariño-Blasco, Sergio (Fundació Privada Hospital Asil de Granollers (Barcelona))
Barahona, María-José (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Franco, Maite (Consorci Sanitari de Terrassa)
Gironès, Xavier (Universitat de Vic)
Crespo Maraver, María Cruz (Fundació Althaia-Xarxa Assistencial Universitària de Manresa (Manresa, Barcelona))
Rovira, Joan Carles (Hospital de Vic)
Castellano-Tejedor, Carmina (Universitat Autònoma de Barcelona)

Data:	2024
Resum:	The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65-85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia, hypertension, and obesity. The primary outcome measures were the participant's scores in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sociodemographic, clinical, and psychosocial data were collected. Non-parametrical statistical analyses and effect sizes were calculated. Findings revealed that a greater presence of CVRFs was not associated with a worse overall cognitive performance. High-risk patients were more likely to have significantly worse performance in the attentional domain compared to medium-risk (p = 0. 029, r = 0. 42) and compared to low-risk (p = 0. 041, r = 0. 35), specifically in the digits repetition subtest (p = 0. 042). T2D alone was the CVRF associated with cognitive differences (p = 0. 037, r = 0. 32), possibly mediated by the duration of the condition. Consequently, a higher presence of CVRFs did not lead to a worse overall cognitive performance. However, high-risk individuals were more likely to experience cognitive impairment, particularly in the attentional domain. T2D played a significant role in these cognitive profile differences, possibly influenced by its duration.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cardiovascular risk factors ; Type 2 diabetes ; Cognitive impairment ; Neuropsychological profile ; Mild cognitive impairment ; Older adults
Publicat a:	International journal of environmental research and public health, Vol. 21 (april 2024) , ISSN 1660-4601

DOI: 10.3390/ijerph21040500
PMID: 38673411

15 p, 396.5 KB

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