Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
Romaní, Natàlia (Vall d'Hebron Institut de Recerca (VHIR))
Pieras, Maria (Vall d'Hebron Institut de Recerca (VHIR))
Frick, Marie Antoinette (Vall d'Hebron Institut de Recerca (VHIR))
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron)
Rodó, Carlota (Hospital Universitari Vall d'Hebron)
Silgado, Aroa (Hospital Universitari Vall d'Hebron)
Suy, Anna (Hospital Universitari Vall d'Hebron)
Espiau, María (Vall d'Hebron Institut de Recerca (VHIR))
Thorne, C. (University College London)
Giaquinto, C. (University Hospital of Padova (Pàdua, Itàlia))
Felipe-Rucián, Ana (Vall d'Hebron Institut de Recerca (VHIR))
Soler-Palacín, Pere (Vall d'Hebron Institut de Recerca (VHIR))
Soriano-Arandes, Antoni (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d'Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7. 3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life.
Ajuts:	European Commission 734857
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adverse outcome ; Arboviruses ; Children ; Congenital infection ; Microcephaly ; Mother-to-child transmission ; Neonate ; Travel-associated ; Zika virus ; Zika virus infection
Publicat a:	Children, Vol. 9 Núm. 10 (october 2022) , p. 1537, ISSN 2227-9067

DOI: 10.3390/children9101537
PMID: 36291474

11 p, 1014.4 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats