European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure
Sacco, Simona (University of L'Aquila)
Lampl, Christian (Headache Medical Center at the Konventhospital BHB Linz)
Amin, Faisal Mohammad (University of Copenhagen)
Braschinsky, Mark (Tartu University Hospital (Tartu, Estònia))
Deligianni, Christina I. (University of Copenhagen)
Uludüz, D. (Istanbul Cerrahpasa Medical Faculty)
Versijpt, Jan (Vrije Universiteit Brussel (VUB))
Ducros, Anne (Montpellier University)
Gil-Gouveia, R. (Universidade Católica Portuguesa)
Katsarava, Z. (University of Duisburg-Essen)
Martelletti, Paolo (Università degli Studi di Roma "La Sapienza")
Ornello, Raffaele (University of L'Aquila)
Raffaelli, B. (Charité-Universitätsmedizin Berlin)
Boucherie, D.M. (Erasmus University Medical Center)
Pozo-Rosich, Patricia (Vall d'Hebron Institut de Recerca (VHIR))
Sánchez del Río, Margarita (Clínica Universidad de Navarra)
Sinclair, A. (Queen Elizabeth Hospital)
Maassen van den Brink, Antoinette (Erasmus Medical Center)
Reuter, U. (Universitätsmedizin Greifswald)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body: The Consensus process included a preliminary literature review, a Delphi round and a subsequent open discussion. According to the Consensus Panel, effective treatment of a migraine attack is to be defined on patient well-being featured by a) improvement of headache, b) relief of non-pain symptoms and c) absence of adverse events. An attack is considered effectively treated if patient's well-being, as defined above, is restored within 2 hours and for at least 24 hours. An individual with migraine is considered as triptan-responder when the given triptan leads to effective acute attack treatment in at least three out of four migraine attacks. On the other hand, an individual with migraine is considered triptan non-responder in the presence of failure of a single triptan (not matching the definition of triptan-responder). The Consensus Panel defined an individual with migraine as triptan-resistant in the presence of failure of at least 2 triptans; triptan refractory, in the presence of failure to at least 3 triptans, including subcutaneous formulation; triptan ineligibile in the presence of an acknowledged contraindication to triptan use, as specified in the summary of product characteristics. The novel definitions can be useful in clinical practice for the assessment of acute attack treatments patients with migraine. They may be helpful in identifying people not responding to triptans and in need for novel acute migraine treatments. The definitions will also be of help in standardizing research on migraine acute care.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Attack ; Ditan ; Gepant ; Headache ; Migraine ; NSAIDs ; Triptan
Publicat a:	Journal of headache and pain, Vol. 23 Núm. 1 (december 2022) , p. 133, ISSN 1129-2377

DOI: 10.1186/s10194-022-01502-z
PMID: 36224519

10 p, 1.8 MB

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