Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder
Zuluaga Blanco, Yenny Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Blanes, Rafael (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernandez Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Miquel, Laia (Hospital Clínic i Provincial de Barcelona)
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Rubio, Gabriel (Hospital 12 de Octubre (Madrid))
Bolao, Ferran (Hospital Universitari de Bellvitge)
Liangpunsakul, Suthat (Indiana University School of Medicine, Indianapolis, Indiana, USA)
Abellí-Deulofeu, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez de Fonseca, Fernando (IBIMA Biomedical Research Institut-Malaga)
Muga, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2024
Descripció:	9 pàg.
Resum:	Background: Effective screening for alcohol-associated liver disease is relevant in the context of chronic, excessive alcohol consumption. Patients with alcohol-associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis-4 index (FIB-4) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD). Methods: We conducted a cross-sectional, multicenter study of noncirrhotic individu-als referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB-4 value ≥2. 67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value. Results: We included 604 patients (67% male), with a median age at admission of 48 years [IQR: 41-56 years]. The median duration of regular alcohol consumption was 21 years [IQR: 18-30 years] and the median alcohol consumption was 105 standard drink units (SDU)/week [IQR: 63-160 SDU/week]. A FIB-4 value ≥ 2. 67 was present in 19. 3% of cases. These patients reported more frequent binge drinking (75. 4% vs. 66%, p= 0. 05) than those with FIB-4 values below 2. 67. In multivariate analysis, a history of binge drinking (OR 1. 9, 95% CI, 1. 05-3. 47), anemia (OR 2. 95, 95% CI, 1. 42-6. 11), leukopenia (OR 7. 46, 95% CI, 2. 07-26. 8), and total serum bilirubin.
Ajuts:	Instituto de Salud Carlos III RD21/0009/0004 Instituto de Salud Carlos III PI20/00883
Nota:	Altres ajuts: acords transformatius de la UAB
Nota:	Altres ajuts: Programa Juan Rodes JR20/00016; Programa Sara Borrell CD19/00019; Agency for Management of University and Research Grants, Government of Catalonia (2021-SGR-00945).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Advanced liver fibrosis ; Alcohol-associated liver disease ; Binge drinking ; FIB-4 index ; Leukopenia
Publicat a:	Alcohol: Clinical and Experimental Research, 2024, p. 1-9, ISSN 1530-0277

DOI: 10.1111/acer.15345
PMID: 38720158

9 p, 542.5 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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