Optical coherence tomography in multiple sclerosis : A 3-year prospective multicenter study
Paul, Friedemann (Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin)
Calabresi, Peter A. (Johns Hopkins Hospital)
Barkhof, Frederik (University College London)
Green, Ari J. (University of California San Francisco)
Kardon, Randy (University of Iowa)
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron)
Schippling, Sven (University Hospital Zurich (Suïssa))
Vermersch, Patrick (Université de Lille)
Saidha, Shiv (Johns Hopkins University)
Gerendas, Bianca S. (Medical University of Vienna)
Schmidt-Erfurth, Ursula (Medical University of Vienna)
Agoropoulou, Catherine (Novartis Pharma AG)
Zhang, Ying (Novartis Pharmaceuticals Corporation)
Seifer, Gustavo (Novartis Pharma AG)
Petzold, Axel (Amsterdam University Medical Center (UMC))
Universitat Autònoma de Barcelona

Data:	2021
Resum:	To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume and disability progression as measured by the Expanded Disability Status Scale (EDSS). Individuals with RRMS from 28 centers (n = 333) were matched with 64 healthy participants. OCT scans were performed on Heidelberg Spectralis machines (at baseline; 1 month; 6 months; 6-monthly thereafter). OCT measurements were highly reproducible between baseline and 1 month (intraclass correlation coefficient >0. 98). Significant inner retinal layer thinning was observed in individuals with multiple sclerosis (MS) compared with controls regardless of previous MS-associated optic neuritis--group differences (95% CI) over 3 years: pRNFL: −1. 86 (−2. 54, −1. 17) µ m; mGCIPL: −2. 03 (−2. 78, −1. 28) µ m (both p < 0. 0001; effect sizes 0. 39 and 0. 34). Greater inner retinal layer atrophy was observed in individuals diagnosed with RRMS <3 years versus >5 years (pRNFL: p < 0. 05; mGCIPL: p < 0. 01). Brain volume decreased by 1. 3% in individuals with MS over 3 years compared to 0. 5% in control subjects (effect size 0. 76). mGCIPL atrophy correlated with brain atrophy (p < 0. 0001). There was no correlation of OCT data with disability progression. OCT has potential to estimate rates of neurodegeneration in the retina and brain. The effect size for OCT, smaller than for magnetic resonance imaging based on Heidelberg Spectralis data acquired in this study, was increased in early disease.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Annals of clinical and translational neurology, Vol. 8 (november 2021) , p. 2235-2251, ISSN 2328-9503

DOI: 10.1002/acn3.51473
PMID: 34792863

17 p, 452.9 KB

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