Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes
Planas, Alejandra (Vall d'Hebron Institut de Recerca (VHIR))
Simó-Servat, Olga (Vall d'Hebron Institut de Recerca (VHIR))
Hernández, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Simó Canonge, Rafael (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The incidence and prevalence of diabetes are increasing worldwide, and cardiovascular disease (CVD) is the leading cause of death among subjects with type 2 diabetes (T2D). The assessment and stratification of cardiovascular risk in subjects with T2D is a challenge. Advanced glycation end products are heterogeneous molecules produced by non-enzymatic glycation of proteins, lipids, or nucleic acids. Accumulation of advanced glycation end products is increased in subjects with T2D and is considered to be one of the major pathogenic mechanism in developing complications in diabetes. Skin AGEs could be assessed by skin autofluorescence. This method has been validated and related to the presence of micro and macroangiopathy in individuals with type 2 diabetes. In this context, the aim of this review is to critically summarize current knowledge and scientific evidence on the relationship between skin AGEs and CVD in subjects with type 2 diabetes, with a brief reference to other diabetes-related complications.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cardiovascular disease ; Advanced glycation end products ; Cardiovascular disease biomarkers ; Diabetic complications ; Diabetic retinopathy ; Type 2 diabetes
Publicat a:	International journal of molecular sciences, Vol. 23 (june 2022) , ISSN 1422-0067

DOI: 10.3390/ijms23116234
PMID: 35682915

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