Network-level macroscale structural connectivity predicts propagation of transcranial magnetic stimulation
Momi, Davide (University of Chieti-Pescara)
Ozdemir, Recep A. (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Tadayon, Ehsan (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Boucher, Pierre (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Shafi, Mouhsin M. (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Santarnecchi, Emiliano (Harvard Medical School)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Information processing in the brain is mediated by structural white matter pathways and is highly dependent on topological brain properties. Here we combined transcranial magnetic stimulation (TMS) with high-density electroencephalography (EEG) and Diffusion Weighted Imaging (DWI), specifically looking at macroscale connectivity to understand whether regional, network-level or whole-brain structural properties are more responsible for stimulus propagation. Neuronavigated TMS pulses were delivered over two individually defined nodes of the default mode (DMN) and dorsal attention (DAN) networks in a group of healthy subjects, with test-retest reliability assessed 1-month apart. TMS-evoked activity was predicted by the modularity and structural integrity of the stimulated network rather than the targeted region(s) or the whole-brain connectivity, suggesting network-level structural connectivity as more relevant than local and global brain properties in shaping TMS signal propagation. The importance of network structural connectome was unveiled only by evoked activity, but not resting-state data. Future clinicals interventions might enhance target engagement by adopting DWI-guided, network-focused TMS.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Default mode network ; Dorsal attention network ; Network ; Structural connectivity ; Transcranial magnetic stimulation
Published in:	NeuroImage, Vol. 229 (december 2020) , p. 117698, ISSN 1095-9572

DOI: 10.1016/j.neuroimage.2020.117698
PMID: 33385561

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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