Role of Leptin in Obesity, Cardiovascular Disease, and Type 2 Diabetes
Vilariño-García, Teresa (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Polonio-González, María L. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Pérez-Pérez, Antonio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Ribalta, Josep (Universitat Rovira i Virgili. Departament de Medicina)
Arrieta, Francisco (Hospital Universitario Ramón y Cajal (Madrid))
Aguilar, Manuel (Universidad de Cádiz)
Obaya, Juan C. (Centro de Salud La Chopera (Alcobenda, Madrid))
Gimeno-Orna, José A. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Iglesias, Pedro (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Navarro, Jorge (Hospital Clínic Universitari (València))
Durán, Santiago (Endodiabesidad Clínica Durán & Asociados)
Pedro-Botet, Juan (Hospital del Mar (Barcelona, Catalunya))
Sánchez-Margalet, Víctor (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in every 11 adults; among them, 90-95% of cases are type 2 diabetes mellitus. This is partly attributed to the surge in the prevalence of obesity, which has reached epidemic proportions since 2008. In these patients, cardiovascular (CV) risk stands as the primary cause of morbidity and mortality, placing a substantial burden on healthcare systems due to the potential for macrovascular and microvascular complications. In this context, leptin, an adipocyte-derived hormone, plays a fundamental role. This hormone is essential for regulating the cellular metabolism and energy balance, controlling inflammatory responses, and maintaining CV system homeostasis. Thus, leptin resistance not only contributes to weight gain but may also lead to increased cardiac inflammation, greater fibrosis, hypertension, and impairment of the cardiac metabolism. Understanding the relationship between leptin resistance and CV risk in obese individuals with type 2 DM (T2DM) could improve the management and prevention of this complication. Therefore, in this narrative review, we will discuss the evidence linking leptin with the presence, severity, and/or prognosis of obesity and T2DM regarding CV disease, aiming to shed light on the potential implications for better management and preventive strategies.
Nota:	Altres ajuts: Junta de Andalucia PAIDI CTS-151
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Type 2 diabetes mellitus ; Obesity ; Leptin ; Cardiovascular risk ; Inflammation
Publicat a:	International journal of molecular sciences, Vol. 25 (february 2024) , ISSN 1422-0067

DOI: 10.3390/ijms25042338
PMID: 38397015

21 p, 1.2 MB

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