Management of Cutaneous Squamous Cell Carcinoma of the Scalp : The Role of Imaging and Therapeutic Approaches
Verdaguer-Faja, Júlia (Universitat Autònoma de Barcelona. Departament de Medicina)
Toll Abelló, Agustí (Hospital Clínic i Provincial de Barcelona)
Boada, Aram (Universitat Autònoma de Barcelona. Departament de Medicina)
Guerra-Amor, Álvaro (Hospital Universitari Vall d'Hebron)
Ferrandiz-Pulido, Carla (Universitat Autònoma de Barcelona. Departament de Medicina)
Jaka, Ane (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2024
Resum:	Cutaneous squamous cell carcinoma is the second most common subtype of skin cancer. The scalp is one of the most frequently affected locations and is associated with a higher risk of complications, compared to other locations. In addition, it has a characteristic thickness and anatomical structure that may influence both growth pattern and treatment of primary cutaneous squamous cell carcinoma; while clinical peripheral margins may be easily achieved during surgery, vertical excision of the tumor is limited by the skull. Despite having a unique anatomy, current guidelines do not offer specific recommendations for cutaneous squamous cell carcinoma of the scalp, which may lead to inconsistent decision-making in multidisciplinary committees when discussing tumors with some risk factors or with close histological margins. Thus, more data are needed to improve its management and assist multidisciplinary teams in shared decisions. Cutaneous squamous cell carcinoma (cSCC) is the second most common subtype of skin cancer. The scalp is one of the most frequently affected locations and is associated with a higher rate of complications, compared to other locations. In addition, it has a characteristic thickness and anatomical structure that may influence both growth pattern and treatment of primary cSCC; while clinical peripheral margins may be easily achieved during the surgery, vertical excision of the tumor is limited by the skull. Despite having a unique anatomy, current guidelines do not contemplate specific recommendations for scalp cSCC, which leads to inconsistent decision-making in multidisciplinary committees when discussing tumors with high risk factors or with close margins. This article provides specific recommendations for the management of patients with scalp cSCC, based on current evidence, as well as those aspects in which evidence is lacking, pointing out possible future lines of research. Topics addressed include epidemiology, clinical presentation and diagnosis, imaging techniques, surgical and radiation treatments, systemic therapy for advanced cases, and follow-up. The primary focus of this review is on management of primary cSCC of the scalp with localized disease, although where relevant, some points about recurrent cSCCs or advanced disease cases are also discussed.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Squamous cell carcinoma ; Cutaneous squamous cell carcinoma ; Scalp ; Head and neck ; Treatment ; Management ; Surgery ; Margins ; Recurrence ; Imaging
Publicat a:	Cancers, Vol. 16 (february 2024) , ISSN 2072-6694

DOI: 10.3390/cancers16030664
PMID: 38339415

24 p, 16.3 MB

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