Unusual congenital goiter due to maternal Hashimoto thyroiditis : a case report
Català, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Casas, Judit (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Yeh, Sean (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Josa-Eritja, Maria (Institut de Recerca Sant Pau)
Tirado Capistros, Mireia (Institut de Recerca Sant Pau)
Moliner, Elisenda (Institut de Recerca Sant Pau)
Carreras, Gemma (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Congenital hypothyroidism (CH) is the most common cause of endocrinopathy in the newborn Its incidence lies between 1 in 3,000 and 1 in 2,000, However, congenital goiter is a rare form of presentation. Hypothyroidism secondary to autoimmune etiology is extremely rare, with an incidence of 1:84. 700-1:31. 000 newborns. Anti-thyroid peroxidase antibodies (TPOAb) are able to cross the placenta but rarely induce hypothyroidism in the newborn, much less goiter. A case of congenital goiter in a male newborn secondary to maternal high TPOAb levels is reported. The mother was diagnosed of Hashimoto thyroiditis prior to the pregnancy. At birth, a grade 3 goiter was detected in the newborn. Laboratory testings revealed hypothyroidism with free thyroxine of 7. 6 pmol/L, thyroid-stimulating hormone of 108 mUI/L and high TPOAb levels. Treatment with Levothyroxine was started the second day of life with progressive thyroid function normalization. Neurological development has been normal until the date.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Autoantibodies ; Congenital hypothyroidism (CH) ; Goiter ; Hypothyroidism ; Newborn
Published in:	Frontiers in Pediatrics, Vol. 12 (2024) , p. 1348431, ISSN 2296-2360

DOI: 10.3389/fped.2024.1348431
PMID: 38840805

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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