Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy : A Multicenter Observational Study
Novo-Veleiro, Ignacio (Complexo Hospitalario Universitario de Santiago)
Herrera Flores, Javier (Hospital Universitario de Salamanca)
Rosón-Hernández, Beatriz (Hospital Universitari de Bellvitge)
Medina-García, José-A. (Hospital Quirónsalud)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández-Solá, Joaquim (Hospital Clínic i Provincial de Barcelona)
Martín-González, M. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Seco-Hernández, Elena (Complexo Hospitalario Universitario de Ourense - CHUO)
Suárez-Cuervo, Carlos (Hospital Universitario Central de Asturias)
Mateos-Díaz, Ana-M. (Hospital Virgen del Puerto. Plasencia)
Monte-Secades, Rafael (Hospital Universitario Lucus Augusti (Lugo))
Machado-Prieto, Begoña (Complexo Hospitalario Universitario de Vigo)
Puerta-Louro, Rubén (Hospital Povisa (Vigo, Pontevedra))
Prada González, Cristina (Hospital Universitario de León)
Fernández-Rial, Álvaro (Complejo Hospitalario Universitario de Ferrol)
Sabio Repiso, Patricia (Hospital Clínico San Carlos (Madrid))
Vázquez-Vigo, Rocío (Complejo Hospitalario Universitario de A Coruña)
Antolí-Royo, Ana Cristina (Complejo Asistencial de Ávila)
Gomila, Aina (Hospital Universitari de Bellvitge)
Felipe-Pérez, Nieves C (Hospital Quirónsalud)
Sanvisens-Bergé, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Antúnez-Jorge, Emilia (Hospital Clínic i Provincial de Barcelona)
Fernández-Rodríguez, Camino M. (Hospital Universitario de Canarias (La Laguna))
Alvela-Suárez, Lucia (HM Rosaleda Hospital. Santiago de Compostela)
Fidalgo-Navarro, Alba (Hospital Universitario Central de Asturias)
Castro, Joaquín (Hospital Santa Bárbara (Puertollano, Ciutat Real))
Polvorosa-Gómez, María A. (Hospital Comarcal de Menorca)
Del Valle-Sánchez, Mario (Hospital General de Soria)
López-Castro, José (Hospital Público de Monforte)
Chamorro, Antonio-J. (Hospital Universitario de Salamanca)
Marcos, Miguel (Hospital Universitario de Salamanca)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2022
Resum:	Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85. 7%), and the mean age was 55 ± 11. 8 years. ALD was present in 162 (37. 3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5. 0%) died during admission (7. 4% with ALD vs 3. 7% without ALD; P = 0. 087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4. 6 Confidence interval [CI]95% 1. 1-18. 8; P = 0. 034), low level of consciousness (OR=4. 9 CI95% 1. 1-21. 2; P = 0. 031) and previous diagnosis of cancer (OR=10. 3 CI95% 1. 8-59. 5; P = 0. 009) was detected. Complete recovery was achieved by 27 patients with ALD (17. 8%) and 71 (27. 8%) without ALD (P = 0. 030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD.
Ajuts:	Ministerio de Economía y Competitividad RD16/0017/0023 Ministerio de Economía y Competitividad RD16/0017/0003 Ministerio de Economía y Competitividad RD16/0017/0018
Nota:	Catedres
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Wernicke encephalopathy ; Alcoholic liver disease ; Alcohol use disorders
Publicat a:	Drug and alcohol dependence, Vol. 230 (january 2022) , ISSN 1879-0046

DOI: 10.1016/j.drugalcdep.2021.109186

6 p, 411.6 KB

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