Spinal facilitation of descending motor input
Taccola, Giuliano (University of Leeds)
Kissane, Roger (Department of Musculoskeletal & Ageing Science, University of Liverpool)
Culaclii, Stanislav (Department of Bioengineering, University of California)
Apicella, Rosamaria (Neuroscience Department, International School for Advanced Studies (UTrieste, Itàlia))
Liu, Wentai (University of California)
Gad, Parag (University of Southern California Neurorestoration Center)
Ichiyama, Ronaldo M. (University of Leeds)
Chakrabarty, Samit (University of Leeds)
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs on the dorsal cord and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.
Ajuts:	European Commission. Horizon 2020 661452
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Neuromodulation ; Noisy waveforms ; Spinal cord ; Cord Dorsum Potentials ; Muscle recruitment ; Spinal reflex ; Epidural neuroprosthesis ; Multielectrode arrays
Publicat a:	bioRxiv, july 2023

DOI: 10.1101/2023.06.30.547229
PMID: 37461548

38 p, 1.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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