CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas
Virgili Manrique, Anna Cristina (Institut de Recerca Sant Pau)
Salazar, Juliana (Institut de Recerca Sant Pau)
Gallardo, Alberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
López Pousa, Antonio (Institut de Recerca Sant Pau)
Terés Lleida, Raúl (Institut de Recerca Sant Pau)
Bagué Rosell, Sílvia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Orellana Fernández, Ruth (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Fumagalli, Caterina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Alba Castellón, Lorena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Unzueta Elorza, Ugutz (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Sebio, Ana (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Poor long-term survival in localized high-risk soft tissue sarcomas (STSs) of the extremities and trunk highlights the need to identify new prognostic factors. CXCR4 is a chemokine receptor involved in tumor progression, angiogenesis, and metastasis. The aim of this study was to evaluate the association between CXCR4 expression in tumor tissue and survival in STSs patients treated with neoadjuvant therapy. CXCR4 expression was retrospectively determined by immunohistochemical analysis in serial specimens including initial biopsies, tumors post-neoadjuvant treatment, and tumors after relapse. We found that a positive cytoplasmatic expression of CXCR4 in tumors after neoadjuvant treatment was a predictor of poor recurrence-free survival (RFS) (p = 0. 003) and overall survival (p = 0. 019) in synovial sarcomas. We also found that positive nuclear CXCR4 expression in the initial biopsies was associated with poor RFS (p = 0. 022) in undifferentiated pleomorphic sarcomas. In conclusion, our study adds to the evidence that CXCR4 expression in tumor tissue is a promising prognostic factor for STSs.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	CXCR4 ; Prognostic factor ; Soft tissue sarcomas ; Synovial sarcomas ; Undifferentiated pleomorphic sarcomas
Published in:	Diagnostics, Vol. 14 Núm. 11 (june 2024) , p. 1195, ISSN 2075-4418

DOI: 10.3390/diagnostics14111195
PMID: 38893721

11 p, 2.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles