Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery : a single-cohort feasibility trial protocol
Boccuni, Leonardo (Institut Germans Trias i Pujol)
Abellaneda Pérez, Kilian (Universitat Autònoma de Barcelona)
Martín-Fernández, Jesús (Universidad de La Laguna)
Leno-Colorado, David (Universitat Autònoma de Barcelona)
Roca-Ventura, Alba (Universitat de Barcelona)
Prats Bisbe, Alba (Universitat Autònoma de Barcelona)
Buloz-Osorio, Edgar (Universitat Autònoma de Barcelona)
Bartrés-Faz, David (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Cabello-Toscano, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Pariente, José Carlos (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Muñoz-Moreno, Emma (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Trompetto, Carlo (IRCCS Ospedale Policlinico San Martino (Gènova, Itàlia))
Marinelli, Lucio (IRCCS Ospedale Policlinico San Martino (Gènova, Itàlia))
Villalba-Martinez, Gloria (Hospital del Mar (Barcelona, Catalunya))
Duffau, Hugues (University of Montpellier)
Pascual Leone, Álvaro (Harvard Medical School)
Tormos, Jose M. (Institut Germans Trias i Pujol. Institut Guttmann)

Date:	2023
Abstract:	Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and the preservation of surrounding brain areas. Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that combines temporary inhibition of critical areas (virtual lesion) with intensive behavioral training to foster the activation of alternative brain resources. By progressively reducing the functional relevance of targeted areas, the goal is to facilitate resection with reduced risks of neurological sequelae. However, it is still unclear which modality (invasive vs. non-invasive neuromodulation) and volume of therapy (behavioral training) may be optimal in terms of feasibility and efficacy. Patients undertake between 10 and 20 daily sessions consisting of neuromodulation coupled with intensive task training, individualized based on the target site and neurological functions at risk of being compromised. The primary outcome of the proposed pilot, single-cohort trial is to investigate the feasibility and potential effectiveness of a non-invasive NICP protocol on neuroplasticity and post-surgical outcomes. Secondary outcomes investigating longitudinal changes (neuroimaging, neurophysiology, and clinical) are measured pre-NICP, post-NICP, and post-surgery. Ethics approval was obtained from the Research Ethical Committee of Fundació Unió Catalana d'Hospitals (approval number: CEI 21/65, version 1, 13/07/2021). The results of the study will be submitted to a peer-reviewed journal and presented at scientific congresses. , identifier NCT05844605.
Grants:	"la Caixa" Foundation LCF/PR/PR16/11110004 Fundació la Marató de TV3 201735.10
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Brain tumor ; Neuro-oncology ; Prehabilitation ; Neuromodulation ; Neurorehabilitation ; Neurosurgery ; Neuroplasticity ; Clinical trial
Published in:	Frontiers in neurology, Vol. 14 (october 2023) , ISSN 1664-2295

DOI: 10.3389/fneur.2023.1243857
PMID: 37849833

14 p, 1.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles