Circulating exosomes decrease in size and increase in number between birth and age 7 : relations to fetal growth and liver fat
Díaz, Marta (Institut de Recerca Sant Joan de Déu)
Casano, Paula (Institut de Recerca Sant Joan de Déu)
Quesada-López, Tania (Institut d'Investigació Biomèdica Sant Pau)
López-Bermejo, Abel (Universitat de Girona)
de Zegher, Francis (University of Leuven)
Villarroya, Francesc (Institut de Recerca Sant Joan de Déu)
Ibáñez, Lourdes (Institut de Recerca Sant Joan de Déu)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Exosomes play a key role in cell-to-cell communication by transferring their cargo to target tissues. Little is known on the course of exosome size and number in infants and children. Longitudinally, we assessed the size and number of circulating exosomes at birth and at ages 2 and 7 yr in 75 infants/children born appropriate-for-gestational-age (AGA; n=40) or small-for-gestational-age (SGA; n=35 with spontaneous catch-up), and related those results to concomitantly assessed measures of endocrine-metabolic health (HOMA-IR; IGF-1), body composition (by DXA at ages 0 and 2) and abdominal fat partitioning (subcutaneous, visceral and hepatic fat by MRI at age 7). Circulating exosomes of AGAs decreased in size (on average by 4. 2%) and increased in number (on average by 77%) between birth and age 7. Circulating exosomes of SGAs (as compared to those of AGAs) had a larger size at birth [146. 8 vs 137. 8 nm, respectively; p=0. 02], and were in lower number at ages 2 [4. 3x10 vs 5. 6x10 particles/mL, respectively; p=0. 01] and 7 [6. 3x10 vs 6. 8x10 particles/mL, respectively; p=0. 006]. Longitudinal changes were thus more pronounced in SGAs for exosome size, and in AGAs for exosome number. At age 7, exosome size associated (P<0. 0001) to liver fat in the whole study population. Early-life changes in circulating exosomes include a minor decrease in size and a major increase in number, and these changes may be influenced by fetal growth. Exosome size may become one of the first circulating markers of liver fat in childhood.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Abdominal fat ; Body composition ; Catch-up growth ; Exosomes ; HMW-adiponectin ; Liver fat ; Small-for-gestational-age
Published in:	Frontiers in endocrinology, Vol. 14 (2023) , p. 1257768, ISSN 1664-2392

DOI: 10.3389/fendo.2023.1257768
PMID: 38027180

9 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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