Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial
Romera Martínez, Irene (Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana)
Avendaño Sola, Cristina (Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana)
Villegas Da Ros, Carolina (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Bosch Llobet, Alba (Institut de Recerca Sant Pau)
García Erce, José Antonio (Banco de Sangre y Tejidos de Navarra)
González Fraile, María Isabel (Centro de Hemoterapia y Hemodonación de Castilla y León)
Guerra Domínguez, Luisa (Hospital Universitario de Gran Canaria Dr. Negrín)
Vicuña Andrés, Isabel (Hospital Universitario de la Princesa (Madrid))
Anguita Velasco, Javier (Hospital General Universitario Gregorio Marañón)
González Rodríguez, Victoria Paz (Hospital Universitario Miguel Servet (Saragossa))
Contreras, Enric (Universitat Autònoma de Barcelona. Banc de Sang i Teixits)
Urcelay Uranga, Sabin (Centro Vasco de Transfusiones y Tejidos Humanos)
Pajares Herraiz, Ángel Luis (Centro Regional de Transfusión Toledo-Guadalajara)
Jimenez-Marco, Teresa (Fundació Banc de Sang i Teixits Illes Balears)
Ojea Pérez, Ana María (Centro Comunitario de Sangre y Tejidos de Asturias)
Arroyo Rodríguez, José Luis (Banco de Sangre y Tejidos de Cantabria)
Pérez-Olmeda, Mayte (Instituto de Salud Carlos III)
Ramos-Martínez, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Velasco-Iglesias, Ana (Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana)
Bueno Cabrera, José Luis (Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana)
Duarte, Rafael (Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels. Four-hundred donors were enrolled in ConPlas-19. The presence and titres of anti-SARS-CoV-2 antibodies were evaluated by EUROIMMUN anti-SARS-CoV-2 S1 IgG ELISA. A majority of 80. 3% of ConPlas-19 donor candidates had positive EUROIMMUN test results (ratio ≥1. 1), and of these, 51. 4% had high antibody titres (ratio ≥3. 5). Antibody levels decline over time, but nevertheless, out of 37 donors tested for an intended second CP donation, over 90% were still EUROIMMUN positive, and nearly 75% of those with high titres maintained high titres in the second sample. Donors with a greater probability of developing high titres of anti-SARS-CoV-2 antibodies include those older than 40 years of age (RR 2. 06; 95% CI 1. 24-3. 42), with more than 7 days of COVID-19 symptoms (RR 1. 89; 95% CI 1. 05-3. 43) and collected within 4 months from infection (RR 2. 61; 95% CI 1. 16-5. 90). Male donors had a trend towards higher titres compared with women (RR 1. 67; 95% CI 0. 91-3. 06). SARS-CoV-2 CP candidate donors' age, duration of COVID-19 symptoms and time from infection to donation associate with the collection of CP with high antibody levels. Beyond COVID-19, these data are relevant to inform decisions to optimize the CP donor selection process in potential future outbreaks.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anti-SARS-CoV-2 ; Convalescent plasma ; COVID-19 ; Donors ; Passive immunotherapy
Published in:	Vox Sanguinis, Vol. 119 Núm. 1 (january 2024) , p. 27-33, ISSN 1423-0410

DOI: 10.1111/vox.13561
PMID: 37986640

7 p, 447.5 KB

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