Association of greenspace exposure with telomere length in preschool children
Miri, Mohammad (Sabzevar University of Medical Sciences. Department of Environmental Health)
de Prado-Bert, Paula (Institut de Salut Global de Barcelona)
Alahabadi, Ahmad (Sabzevar University of Medical Sciences. Department of Environmental Health)
Najafi, Moslem Lari (Kerman University of Medical Sciences. Pharmaceutical Sciences and Cosmetic Products Research Center)
Rad, Abolfazl (Sabzevar University of Medical Sciences. Cellular and Molecular Research Center)
Moslem, Alireza (Sabzevar University of Medical Sciences. Cellular and Molecular Research Center)
Aval, Hamideh Ebrahimi (Sabzevar University of Medical Sciences. Cellular and Molecular Research Center)
Ehrampoush, Mohammad Hassan (Shahid Sadoughi University of Medical Sciences. Department of Environmental Health)
Bustamante, Mariona (Institut de Salut Global de Barcelona)
Zare Sakhvidi, Mohammad Javad (Université de Rennes 1. Institut de Recherche en Santé, Environnement et Travail)
Nawrot, Tim (Hasselt University. Centre for Environmental Sciences)
Sunyer, Jordi (Institut de Salut Global de Barcelona)
Dadvand, Payam (Institut de Salut Global de Barcelona)

Data:	2020
Resum:	Exposure to greenspace has been associated with a wide range of health benefits; however, the available evidence on the association of this exposure with telomere length (TL), an early marker of ageing, is still scarce. We investigated the association of greenspace exposure with TL in a sample of 200 preschool children (aged 5-7 years) residing in Sabzevar, Iran (2017). We comprehensively characterized different aspects of greenspace exposure encompassing residential, kindergarten, and total (including both residential and kindergarten) surrounding greenspace (using satellite-derived Normalized Difference Vegetation Index), residential and kindergarten distance to green spaces, time spent in private gardens and public green spaces, and the number of plant pots at home. Relative leukocyte TL (LTL) in blood samples of the study participants was measured using quantitative polymerase chain reaction (qPCR). We applied mixed effects linear regression models with kindergarten and qPCR plate as random effects, to estimate the association of indicators of greenspace exposure (one at a time) with LTL, controlled for relevant covariates. We observed an inverse association between distance from home and kindergarten to green spaces larger than 5000 m2 and LTL. Moreover, higher total surrounding greenspace at 300m and 500m buffers and higher surrounding greenspace at 300m buffer around kindergarten and home were associated with longer LTL. Furthermore, longer time spent (h/week) in the public green spaces was associated with longer LTL. Our findings for residential and kindergarten distance to any green space (regardless of the size), residential surrounding greenspace at 100m and 500m buffers, kindergarten surrounding greenspace at 100m buffer, time spent in private gardens (h/week) and the number of plant pots at home were not conclusive. Our findings were generally suggestive for a positive association between greenspace exposure and LTL in preschool children. More studies are needed to confirm these findings in other settings with different climates and populations.
Ajuts:	Ministerio de Economía y Competitividad RYC-201210995
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Ageing ; Development ; LMICs ; Natural environments ; Pediatric ; Urbanization
Publicat a:	Environmental pollution (1987), Vol. 266, Part 1 (November 2020) , art. 115228, ISSN 1873-6424

DOI: 10.1016/j.envpol.2020.115228
PMID: 32763773

Postprint 36 p, 795.8 KB

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