Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners : The Perseo study
Marco, Andrés (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Antón, José J. (Centro Penitenciario de Albolote)
Trujols, Joan (Institut d'Investigació Biomèdica Sant Pau)
Saíz de la Hoya, Pablo (Centro Penitenciario Fontcalent)
de Juan, José (Centro Penitenciario de Córdoba)
Faraco, Inmaculada (Centro Penitenciario Sevilla)
Caylà, Joan A. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal

Date:	2015
Abstract:	Background: The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. Methods: We performed a prospective multicentre study in inmates from 25 Spanish prisons who had been treated with pegylated interferon alfa-2a plus ribavirin in 2011. PD diagnosis was based on the Personality Diagnostic Questionnaire-4+. We calculated adjusted Odds Ratios (AOR) and 95% confidence intervals (95% CI) using logistic regression. Results: The sample included 236 patients (mean age: 40. 3years, 92. 8% male, 79. 2% intravenous drug users, and 26. 3% HIV-coinfected). The prevalence of PD was 72. 5%. 32. 2% of patients discontinued treatment; this percentage was higher in patients with HCV genotypes 1/4 (AOR=3. 55; CI:1. 76-7. 18) and those without PD (AOR=2. 51; 1. 23-5. 11). Treatment discontinuation was mainly for penitentiary reasons (40. 3%): release or transfer between prisons. The rate of sustained viral response (SVR) was 52. 1% by ITT and 76. 9% by observed treatment (OT). SVR was higher among patients with genotype 2 or 3, and those with low baseline HCV-RNA. We did not observe any differences between individuals with and without PD in term of SVR, HCV genotype or HIV infection. Conclusions: Our results support the safety and clinical effectiveness of the treatment of chronic HCV infection in correctional facilities, both in prisoners with PD and those without. Our data support non-discrimination between patients with and without PD when offering treatment for HCV infection to prison inmates. Trial registration: Trial registration number (TRN) NCT01900886. Date of registration: July 8, 2013.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adult ; Antiviral Agents ; Coinfection ; Drug Therapy, Combination ; Female ; Genotype ; Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic ; HIV Infections ; Humans ; Interferon-alpha ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Personality Disorders ; Polyethylene Glycols ; Prisoners ; Prisons ; Prospective Studies ; Recombinant Proteins ; Ribavirin ; Spain ; Treatment Outcome ; Young Adult
Published in:	BMC Infectious diseases, Vol. 15 Núm. 1 (august 2015) , p. 355, ISSN 1471-2334

DOI: 10.1186/s12879-015-1102-x
PMID: 26286450

9 p, 606.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles