Physicochemical Compatibility of Ceftolozane-Tazobactam with Parenteral Nutrition
De Pourcq, Jan T (Institut de Recerca Sant Pau)
Riera, Adria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gras, Laura (Institut de Recerca Sant Pau)
Garin, Noe (Institut de Recerca Sant Pau)
Busquets, M. Antònia (Universitat de Barcelona)
Cardenete, Joana (Institut de Recerca Sant Pau)
Cardona, Daniel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Riera, Pau (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Ceftolozane-tazobactam (CT) is used for the treatment of complicated infections and for multidrug-resistant strains of Pseudomonas aeruginosa and extended-spectrum beta-lactamase-producing enterobacteria. In certain cases, simultaneous administration of CT and parenteral nutrition (PN) may be required, but compatibility of Y-site co-administration is unknown. The aim of this study was to analyse the physicochemical compatibility of CT Y-site administered with PN. We evaluated a protocolized PN approach for critical patients in our center. We studied both bolus infusion (2 g ceftolozane/1 g tazobactam in 1 h) and continuous infusion (CI) (6 g ceftolozane/3 g tazobactam) strategies. Samples were visually observed against light, microscopically inspected, and pH was analysed using a pH meter. The mean lipid droplet diameter (MDD) was determined via dynamic light scattering. CT concentration was quantified using HPLC-HRMS. No alterations were observed through visual or microscopic inspection. Changes in pH were ≤0. 2, and changes in osmolarity were less than 5%. MDD remained below 500 nm (284. 5 ± 2. 1 for bolus CT and 286. 8 ± 7. 5 for CI CT). CT concentrations at t = 0 h and t = 24 h remained within prespecified parameters in both infusion strategies. CT is physiochemically compatible with PN during simulated Y-site administration at the tested concentration and infusion rates.
Grants:	Instituto de Salud Carlos III JR20/00008 Ministerio de Ciencia, Innovación y Universidades EQC2019-005533-P
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Pharmaceuticals, Vol. 17 Núm. 7 (july 2024) , p. 896, ISSN 1424-8247

DOI: 10.3390/ph17070896
PMID: 39065746

13 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles