Circulating endothelial progenitor cells and the risk of vascular events after ischemic stroke
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau)
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau)
Crespo, Javier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau)
Marín, Rebeca (Institut d'Investigació Biomèdica Sant Pau)
Jiménez Xarrié, Elena (Institut d'Investigació Biomèdica Sant Pau)
Fernández-Arcos, Ana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Pérez-Pérez, Jesús (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Domeño, Alejandro (Institut d'Investigació Biomèdica Sant Pau)
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau)
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau)
Casoni, Francesca (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2015
Abstract:	Background and Purpose We evaluated the hypothesis that the number of circulating EPC could be associated with the risk of stroke recurrence (SR) or vascular events (VE) after an ischemic stroke. Methods We studied prospectively consecutive patients with cerebral infarction within the first 48 hours after the onset. We recorded demographic factors, vascular risk factors, previous Rankin scale (RS) score, and etiology. We analyzed EPC counts by flow cytometry in blood collected at day 7 and defined EPC as CD34+/CD133+/KDR+ cells. Mean follow-up was 29. 3 ± 16 months. We evaluated SR as well as VE. Patients were classified as to the presence or absence of EPC in the circulation (either EPC+ or EPC-). Bivariate analyses, Kaplan-Meier survival curves and Cox regression models were used. Results We included 121 patients (mean age 70. 1±12. 6 years; 65% were men). The percentage of EPC+ patients was 47. 1%. SR occurred in 12 (9. 9%) and VE in 18 (14. 9%) patients. SR was associated significantly with a worse prior RS score, previous stroke and etiology, but not with EPC count. VE were associated significantly with EPC-, worse prior RS score, previous stroke, high age, peripheral artery disease and etiology. Cox regression model showed that EPC- (HR 7. 07, p=0. 003), age (HR 1. 08, p=0. 004) and a worse prior RS score (HR 5. 8, p=0. 004) were associated significantly with an increased risk of VE. Conclusions The absence of circulating EPC is not associated with the risk of stroke recurrence, but is associated with an increased risk of future vascular events.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Age Factors ; Aged ; Aged, 80 and over ; Antigens, CD ; Biomarkers ; Cerebral Infarction ; Endothelial Progenitor Cells ; Female ; Gene Expression ; Humans ; Male ; Middle Aged ; Peripheral Arterial Disease ; Prospective Studies ; Recurrence ; Risk Factors ; Survival Analysis
Published in:	PloS one, Vol. 10 Núm. 4 (13 2015) , p. e0124895, ISSN 1932-6203

DOI: 10.1371/journal.pone.0124895
PMID: 25874380

11 p, 348.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles