Drug-eluting stent thrombosis in the treatment of chronic total coronary occlusions : Incidence, presentation and related factors. Data from the CIBELES trial
Arroyo-Úcar, Eduardo (Hospital Universitario La Paz (Madrid))
Moreno, Raúl (Hospital Universitario La Paz (Madrid))
García, Eulogio (Hospital Clínico (Madrid))
Teles, Rui (Hospital de Santa Cruz (Lisboa))
Rumoroso, José Ramon (Hospital de Galdakao (Usansolo, Biscaia))
Carvalho, Henrique Cyrne (Hospital de Santo Antonio (Porto))
Goicolea, Francisco Javier (Hospital Puerta de Hierro (Madrid))
Moreu, José (Hospital Virgen de la Salud (Toledo))
Mauri, Josefa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sabaté Tenas, Manel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Mainar, Vicente (Hospital General (Alacant))
Patricio, Lino (Hospital de Santa Marta (Lisboa))
Valdés, Mariano (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Fernández-Vázquez, Felipe (Complejo Hospitalario (León))
Sánchez-Recalde, Ángel (Hospital Universitario La Paz (Madrid))
Galeote, Guillermo (Hospital Universitario La Paz (Madrid))
Jimenez-Valero, Santiago (Hospital Universitario La Paz (Madrid))
Almeida, Manuel (Hospital de Santa Cruz (Lisboa))
López De Sa, Esteban (Hospital Universitario La Paz (Madrid))
Calvo, Luis (Hospital Universitario La Paz (Madrid))
Plaza, Ignacio (Hospital Universitario La Paz (Madrid))
Lopez-Sendón, José Luis (Hospital Universitario La Paz (Madrid))
Martín, José Luis R. (Universidad Europea de Madrid)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	Abstract: Introduction and Objectives The aim of this study was to analyze the incidence of drug-eluting stent thrombosis (sirolimus or everolimus) in patients with chronic total coronary occlusions (CTO) and to determine its clinical implications and related factors. Methods Data from the 12-month follow-up of the 207 patients included in the CIBELES trial with CTO were analyzed. Results Stent thrombosis occurred in three patients, two definite and one probable (overall thrombosis rate: 1. 4%). However, there were no cases of death or Q-wave myocardial infarction. In univariate analysis, patients with a higher incidence of stent thrombosis were those in whom the target vessel was the left anterior descending, who had single-vessel disease, were assigned to treatment with sirolimus-eluting stents, and those with smaller minimum luminal diameter immediately after the procedure. In multivariate analysis, the only independent predictor of stent thrombosis was minimal luminal diameter immediately after the procedure. Conclusions The rate of drug-eluting stent thrombosis in patients with CTO is relatively low (1. 4%). The only independent predictor of stent thrombosis in this context was minimal luminal diameter after the procedure and the clinical presentation was in all cases relatively benign.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic total coronary occlusion ; Everolimus ; Sirolimus ; Stent ; Thrombosis
Publicat a:	Revista Portuguesa de Cardiologia, Vol. 34 Núm. 3 (january 2015) , p. 193-199, ISSN 2174-2030

DOI: 10.1016/j.repc.2014.08.026
PMID: 25686520

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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