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| Pàgina inicial > Articles > Articles publicats > Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial |
(The University of Sydney) (School of Biotechnology and Biomolecular Sciences) (The University of Sydney) (University of California Santa Cruz) (School of Biotechnology and Biomolecular Sciences) (Macquarie University) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") (University of California Santa Cruz) (School of Biotechnology and Biomolecular Sciences) (The University of Sydney) (Australian Museum Research Institute) (The University of Sydney) (The University of Sydney) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) (La Trobe University) (University of Melbourne) (University of California Santa Cruz) (Biodiversity and Conservation Science)| Data: | 2024 |
| Resum: | Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-level genome assembly (3. 66 Gbp) and genome sequences for the extinct Yallara (lesser bilby, Macrotis leucura). We developed and tested a scat single-nucleotide polymorphism panel to inform current and future conservation actions, undertake ecological assessments and improve our understanding of Ninu genetic diversity in managed and wild populations. We also assessed the beneficial impact of translocations in the metapopulation (N = 363 Ninu). Resequenced genomes (temperate Ninu, 6; semi-arid Ninu, 6; and Yallara, 4) revealed two major population crashes during global cooling events for both species and differences in Ninu genes involved in anatomical and metabolic pathways. Despite their 45-year captive history, Ninu have fewer long runs of homozygosity than other larger mammals, which may be attributable to their boom-bust life history. Here we investigated the unique Ninu biology using 12 tissue transcriptomes revealing expression of all 115 conserved eutherian chorioallantoic placentation genes in the uterus, an XYY sex chromosome system and olfactory receptor gene expansions. Together, we demonstrate the holistic value of genomics in improving key conservation actions, understanding unique biological traits and developing tools for Indigenous rangers to monitor remote wild populations. |
| Ajuts: | Agencia Estatal de Investigación PID2020-112557GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-122 Ministerio de Ciencia, Innovación y Universidades FPU18/03867 Ministerio de Ciencia, Innovación y Universidades EST22/00661 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Publicat a: | Nature ecology & evolution, Vol. 8 (July 2024) , p. 1311-1326, ISSN 2397-334X |
| Obra relacionada: | Hogg, Carolyn J.; Edwards, Richard J.; Farquharson, Katherine A.; [et al.]. «Author Correction : Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial». Nature ecology & evolution, Vol. 8 (July 2024), art. 1776 https://doi.org/10.1038/s41559-024-02519-0 |
