Risk Factors Associated with Antibiotic Exposure Variability in Critically Ill Patients : A Systematic Review
Gras-Martin, Laura (Institut de Recerca Sant Pau)
Zarate-Tamames, Borja (Institut de Recerca Sant Pau)
Vera-Artazcoz, Paula (Universitat Autònoma de Barcelona. Departament de Medicina)
Torres Bonafonte, Olga H. (Universitat Autònoma de Barcelona. Departament de Medicina)
Bastida, Carla (Hospital Clínic i Provincial de Barcelona)
Soy, Dolors (Hospital Clínic i Provincial de Barcelona)
Ruiz Ramos, Jesús (Institut de Recerca Sant Pau)
Plaza-Diaz, Adrián (Institut de Recerca Sant Pau)

Fecha:	2024
Resumen:	(1) Background: Knowledge about the behavior of antibiotics in critically ill patients has been increasing in recent years. Some studies have concluded that a high percentage may be outside the therapeutic range. The most likely cause of this is the pharmacokinetic variability of critically ill patients, but it is not clear which factors have the greatest impact. The aim of this systematic review is to identify risk factors among critically ill patients that may exhibit significant pharmacokinetic alterations, compromising treatment efficacy and safety. (2) Methods: The search included the PubMed, Web of Science, and Embase databases. (3) Results: We identified 246 observational studies and ten clinical trials. The most studied risk factors in the literature were renal function, weight, age, sex, and renal replacement therapy. Risk factors with the greatest impact included renal function, weight, renal replacement therapy, age, protein or albumin levels, and APACHE or SAPS scores. (4) Conclusions: The review allows us to identify which critically ill patients are at a higher risk of not reaching therapeutic targets and helps us to recognize the extensive number of risk factors that have been studied, guiding their inclusion in future studies. It is essential to continue researching, especially in real clinical practice and with clinical outcomes.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Pharmacokinetics ; Pharmacodynamics ; Critically ill patients ; Antibiotic ; Exposure ; Target attainment ; Risk factors
Publicado en:	Antibiotics, Vol. 13, Núm. 9 (august 2024) , ISSN 2079-6382

DOI: 10.3390/antibiotics13090801
PMID: 39334976

27 p, 2.5 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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