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| Pàgina inicial > Articles > Articles publicats > Lower serum ferritin levels are associated with worse cognitive performance in aging |
(Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari de Girona Doctor Josep Trueta) (Universitat de Girona. Departament de Medicina) (Universitat de Girona. Departament d'Infermeria) (Universitat de Girona) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari de Girona Doctor Josep Trueta)
| Data: | 2024 |
| Resum: | Objectives: Iron is important for neurogenesis, synaptic development, and neurotransmitter synthesis. Serum ferritin (SF) is a reliable marker for assessing iron stores. Therefore, we evaluated the cognitive function associated with SF levels. We also assessed brain iron content using R2* Magnetic Resonance Imaging (MRI) and its association with SF levels. Design: Data from three cross-sectional observational studies were used. Aging Imageomics (n = 1030) was conducted on aged subjects. Health Imageomics (n = 971) and IR0NMET (n = 175) were conducted in middle-aged subjects. Setting and participants: Participants were enrolled at Dr. Josep Trueta University Hospital facilities. The three cohorts included a total of 2176 subjects (mean age, 52 years; 48% men). Measurements: SF levels were measured by standard laboratory methods. Total Digits Span (TDS), and Phonemic Verbal Fluency (PVF) were used to assess executive function. Language function was assessed by semantic verbal fluency (SVF), attention by the Symbol Digit Modalities Test, and memory by the Memory Binding Tests - Total Free Recall and Total Delayed Free Recall. MRI was used to assess the iron content of the brain by R2*. Results: In subjects aged 65 years or older, SF levels were associated with increased TDS (β = 0. 003, p = 0. 02), PVF (β = 0. 004, p = 0. 01), and SVF (β = 0. 004, p = 0. 002) scores. After stratification by sex, these findings were significant only in men, where SF was associated with increased TDS (β = 0. 003, p = 0. 01), PVF (β = 0. 004, p = 0. 03), and SVF (β = 0. 004, p = 0. 009) scores. In middle-aged subjects, SF was also associated with increased SVF scores (β = 0. 005, p = 0. 011). Lastly, in men, SF levels were negatively associated with R2*, a surrogate marker of brain iron content, in both the left frontal inferior opercular area (r = -0. 41, p = 0. 005) and the right frontal inferior opercular area (r = -0. 44, p = 0. 002). Conclusions: SF is significantly and positively associated with cognition. In older people with low SF levels, iron supplementation may be a promising therapy to improve cognition. |
| Ajuts: | Ministerio de Economía y Competitividad PI15/01934 Instituto de Salud Carlos III PI18/01022 Instituto de Salud Carlos III PI21/01361 Instituto de Salud Carlos III PI20/01090 Instituto de Salud Carlos III PI23/00575 European Commission 859890 Generalitat de Catalunya SLT002/16/00250 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01263 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Cognition ; Iron stores ; Ferritin ; Brain iron ; Epidemiology |
| Publicat a: | The Journal of nutrition, health and aging, Vol. 28 Núm. 4 (april 2024) , p. 100190, ISSN 1760-4788 |
