The African introgression of Murciano Granadina goats has a Moroccan origin and displays remarkable levels of inter-individual variability
Petretto, Elena (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Luigi Sierra, Maria Gracia (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Vacca, Giuseppe Massimo (Università di Sassari)
Martinez, Amparo (Universidad de Córdoba. Departamento de Genética)
Delgado Bermejo, Juan Vicente (Universidad de Córdoba. Departamento de Genética)
Fernández Álvarez, Javier (Universidad de Córdoba. Departamento de Genética)
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Pazzola, Michele (Università di Sassari)
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Dettori, Maria Luisa (Università di Sassari)
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data:	2024
Resum:	There is evidence that Murciano Granadina (MG), the most important caprine dairy breed in Spain, has been introgressed by African goats, but the precise geographic origin of such introgression has not been identified yet. Moreover, an accurate estimate of the magnitude of this African introgression is lacking, since current estimates are based on small numbers of sampled individuals. The aim of our work was to tackle these two issues by genotyping 500 MG goats with the Goat SNP50 BeadChip and comparing their genotypes with those of reference populations from Spain (Bermeya), France (Saanen), Morocco (Barcha, Draa, Ghazalia, Noire de Atlas, Nord, Moroccan), Egypt (Barki, Oasis, Saidi), Algeria (Arabia, Makatia, M'Zabite, Kabyle), Tunisia (Tunisian native breeds) and Sudan (Desert, Nilotic, Taggar). The population of 500 MG goats was subdivided into 10 datasets of 50 individuals to ensure that sample sizes of the target (MG) and reference populations are balanced. Performance of an unsupervised ADMIXTURE analysis demonstrated that MG goats have a North African ancestry, with an average proportion of 4. 4 ± 2. 3%. Next, we did a supervised ADMIXTURE analysis that revealed that the Moroccan genetic component reaches a proportion of 4. 01 ± 3. 9% in MG goats, while the Algerian (0. 001 ± 0. 001%), Egyptian (0. 2 ± 0. 1%), Sudanese (0. 1 ± 0. 1%) and Tunisian (0. 3 ± 0. 4%) components are present in extremely small proportions. The historical circumstances of this introgression event are currently unknown, but several plausible scenarios are outlined. Moreover, our results show considerable inter-individual heterogeneity regarding the magnitude of the Moroccan introgression of MG goats (0%- 12% depending on the MG data set under analysis). This result implies that reliable estimates about the introgression of autochthonous livestock by exotic breeds can only be obtained by extensively sampling target populations.
Ajuts:	Agencia Estatal de Investigación PID2019-105805RB-I00 Agencia Estatal de Investigación PID2022-136834OB-I00 Ministerio de Economía y Competitividad BES-C-2017-079709 European Commission POR-FSE 2014/2020
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Admixture ; Goat ; High-density SNP arrays ; Introgression ; Murciano Granadina
Publicat a:	Animal genetics, 2024 , ISSN 1365-2052

DOI: 10.1111/age.13472
PMID: 39291549

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