Vitamin D concentrations in familial combined hyperlipidemia : Effects of lipid lowering treatment
Miñambres, Inka (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Hernández, Joan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Rodríguez, José (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
De Leiva Hidalgo, Alberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2014
Resum:	Background: Vitamin D deficiency has been linked to several cardiovascular risk factors but information regarding vitamin D concentrations in familial combined hyperlipidemia (FCHL) is lacking. Our objective was to examine vitamin D concentrations in patients with FCHL and to study the effects of lipid-lowering therapy. Methods. We conducted a cross sectional study on 59 patients with FCHL and 48 healthy controls. We analyzed 25-hydroxyvitamin D (25(OH)D) concentrations and their association with lipid parameters, anthropometric measures, C-reactive protein and homeostasis model assessment (HOMA) index. Twenty-three patients with FCHL were also included in a longitudinal study conducted to analyze 25-hydroxyvitamin D concentrations before and after treatment for dyslipidemia. Results: After adjustment for body mass index and seasonality, patients with FCHL had lower vitamin D concentrations than controls. Adjusted means (standard error of the mean (S. E. M)) for 25(OH)D according to the presence or absence of FCHL were 62. 8 (3. 6) nmol/L for patients with FCHL and 74. 8 (4. 1) nmol/L for controls (p = 0. 021). In FCHL, hypovitaminosis D was associated with features of atherogenic dyslipidemia. After lipid-lowering therapy, vitamin D concentrations increased (51. 0 ± 31. 3 to 58. 9 ± 24. 6 nmol/L (P = 0. 022)). However, changes in 25(OH)D concentrations did not correlate with changes in other parameters. Conclusions: Our findings suggest that FCHL is associated with decreased vitamin D concentrations and that treatment for dyslipidemia improves vitamin D status through an unknown mechanism. Further studies are needed to replicate these data in larger populations and to elucidate the mechanisms involved in this association. © 2014 Miñambres et al. ; licensee BioMed Central Ltd.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Dyslipidemia ; Familial combined hyperlipidemia ; Insulin resistance ; Metabolic syndrome ; Vitamin D
Publicat a:	Diabetology & metabolic syndrome, Vol. 6 Núm. 1 (22 2014) , p. 7, ISSN 1758-5996

DOI: 10.1186/1758-5996-6-7
PMID: 24450309

6 p, 196.4 KB

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