Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals
Massanella, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ouchi, Dan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marfil, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Llibre, Josep M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puertas, Maria C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Buzón, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Richman, Douglas D. (University of California San Diego)
Orna, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Stevenson, Mario (University of Miami)
Gatell, Josep M. (Hospital Clínic i Provincial de Barcelona)
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Blanco, Julià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2014
Abstract:	Background: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. Methods: Longitudinal plasma samples (0-48 weeks) from the IntegRal (n=67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts,350 cells/μl, 14 control and 30 intensified) were assayed for 25 markers. Mann-Whitney, Wilcoxon, Spearman test and linear mixed models were used for analysis. Results: At baseline, different inflammatory markers were strongly associated with HCV co-infection, lower CD4 counts and with cART regimens (being higher in PI-treated individuals), but poorly correlated with detection of markers of residual viral replication. Although raltegravir intensification reduced inflammation in individuals with lower CD4 T-cell counts, no effect of intensification was observed on plasma markers of inflammation in a global analysis. An association was found, however, between reductions in immune activation and plasma levels of the coagulation marker D-dimer, which exclusively decreased in intensified patients on protease inhibitor (PI)-based cART regimens (P=0. 040). Conclusions: The inflammatory profile in treated HIV-infected individuals showed a complex association with HCV co-infection, the levels of CD4 T cells and the cART regimen. Raltegravir intensification specifically reduced D-dimer levels in PI-treated patients, highlighting the link between cART composition and residual viral replication; however, raltegravir had little effect on other inflammatory markers.
Grants:	Ministerio de Economía y Competitividad RD12/0017/0002
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adult ; Biomarkers ; Female ; HIV Infections ; HIV Integrase Inhibitors ; Humans ; Inflammation ; Male ; Middle Aged ; Prospective Studies ; Raltegravir Potassium
Published in:	PloS one, Vol. 9 Núm. 12 (february 2014) , p. e114142, ISSN 1932-6203

DOI: 10.1371/journal.pone.0114142
PMID: 25462535

15 p, 906.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles