Inflammatory biomarkers in type 2 diabetic patients : Effect of glycemic control and impact of ldl subfraction phenotype
Vinagre, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Hernández, Juan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Santos, David (Institut d'Investigació Biomèdica Sant Pau)
Ordóñez, J. (Jordi), 1952- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
De Leiva Hidalgo, Alberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2014
Resum:	Background: Type 2 diabetes mellitus (T2D) is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. The aim of this study was to determine the association of inflammatory biomarkers with low-density lipoprotein (LDL) subfraction phenotype and glycemic control in subjects with T2D and poor glycemic control. Methods: A cross-sectional study was performed comparing 122 subjects with T2D (59 ± 11 years old, body mass index 30. 2 ± 5. 6 kg/m2) with 54 control subjects. Patients with T2D were classified according to their LDL subfraction phenotype and inflammatory biomarkers (C-reactive protein, Interleukin-6, Interleukin-8, Transforming growth factor β, Monocyte chemotactic protein 1, Leptin, Adiponectin) were evaluated according to the degree of glycemic control, LDL phenotype and other clinical characteristics. Forty-two subjects with T2D were studied before and after 3 months of improving glycemic control by different strategies. Results: Patients with T2D had higher C-reactive protein (CRP) and monocyte chemotactic protein-1 (MCP1) levels and lower adiponectin concentration, compared to controls. T2D subjects with body mass index ≥ 30 kg/m2 had higher CRP levels (5. 2 ± 4. 8 mg/l vs 3. 7 ± 4. 3 mg/l; p < 0. 05). The presence of LDL phenotype B was related to higher levels of transforming growth factor-β (TGF-β) (53. 92 ± 52. 82 ng/l vs 31. 35 ± 33. 74 ng/l; p < 0. 05) and lower levels of adiponectin (3663 ± 3044 ng/l vs 2723 ± 1776 ng/l; p < 0. 05). The reduction of HbA1c from 9. 5 ± 1. 8% at baseline to 7. 4 ± 0. 8% was associated with a significant reduction of TGF-β (41. 86 ± 32. 84 ng/l vs 26. 64 ± 26. 91 ng/l; p = 0. 02). Conclusions: Subjects with T2D, especially those with LDL phenotype B and obesity, have higher levels of inflammatory biomarkers. Improvement of glycemic control reduces TGF-β levels, which may contribute partly to its renoprotective role. © 2014 Vinagre et al. ; licensee BioMed Central Ltd.
Ajuts:	Ministerio de Economía y Competitividad RD12/0042/0043
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adiponectin ; Atherogenic dyslipidemia ; C-reactive protein ; Inflammatory biomarkers ; LDL phenotype ; Monocyte chemotactic protein-1 ; Transforming growth factor-β1 ; Tumor growth factor β1 ; Type 2 diabetes
Publicat a:	Cardiovascular diabetology, Vol. 13 Núm. 1 (april 2014) , p. 34, ISSN 1475-2840

DOI: 10.1186/1475-2840-13-34
PMID: 24495560

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