Antimicrobial Pharmacokinetics and Pharmacodynamics in Critical Care : Adjusting the Dose in Extracorporeal Circulation and to Prevent the Genesis of Multiresistant Bacteria
Ruiz Ramos, Jesús (Institut d'Investigació Biomèdica Sant Pau)
Gras-Martin, Laura (Institut d'Investigació Biomèdica Sant Pau)
Ramírez, Paula (Hospital Universitari i Politècnic La Fe (València))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Critically ill patients suffering from severe infections are prone to pathophysiological pharmacokinetic changes that are frequently associated with inadequate antibiotic serum concentrations. Minimum inhibitory concentrations (MICs) of the causative pathogens tend to be higher in intensive care units. Both pharmacokinetic changes and high antibiotic resistance likely jeopardize the efficacy of treatment. The use of extracorporeal circulation devices to support hemodynamic, respiratory, or renal failure enables pharmacokinetic changes and makes it even more difficult to achieve an adequate antibiotic dose. Besides a clinical response, antibiotic pharmacokinetic optimization is important to reduce the selection of strains resistant to common antibiotics. In this review, we summarize the present knowledge regarding pharmacokinetic changes in critically ill patients and we discuss the effects of extra-corporeal devices on antibiotic treatment together with potential solutions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Antibiotic activity ; Antibiotic resistance ; Intensive care unit ; Multidrug-resistant pathogens ; Pharmacokinetics
Published in:	Antibiotics, Vol. 12 Núm. 3 (march 2023) , p. 475, ISSN 2079-6382

DOI: 10.3390/antibiotics12030475
PMID: 36978342

14 p, 338.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles