Placental site trophoblastic tumor (PSTT) : a case report and review of the literature
Zampacorta, Claudia (University Chieti-Pescara (Chieti, Itàlia))
Pasciuto, Maria Paola (University Chieti-Pescara (Chieti, Itàlia))
Ferro, Benedetta (University Chieti-Pescara (Chieti, Itàlia))
Lucidi, Alessandro (University of Chieti (Chieti, Itàlia))
Sánchez Maestro, Ángel (Hospithal Vithas Medimar (Alacant, País Valencià))
Espinosa, Iñigo (Institut d'Investigació Biomèdica Sant Pau)
D'Angelo, Emanuela (University "G. D'Annunzio" of Chieti-Pescara (Chieti, Itàlia))
Prat, Jaime (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Placental site trophoblastic tumor (PSTT), also known as atypical choriocarcinoma, syncytioma, chorioepitheliosis or trophoblastic pseudotumor, is a rare gestational trophoblastic disease (0. 25-5% of all trophoblastic tumors) and it is composed by neoplastic proliferation of intermediate trophoblasts at placental implantation site. It consists of aggregates or sheets of large, polyhedral to round, predominantly mononucleated cells with a characteristic vascular and myometrial invasion. Main differential diagnoses are gestational choriocarcinoma (GC) and epitelioid trophoblastic tumor (ETT). We present a case of PSTT in a 25-year-old woman. Neoplastic cells showed moderate/high nuclear pleomorphism, abundant amphophilic, eosinophilic and clear cytoplasm, numerous mitotic figures (10 mitoses/10 HPF), and myometrial invasion. Other features are necrosis, vascular invasion with replacement of myometrial vessels by tumor cells and hemorrhage. The patient showed typical low serum β-hCG levels and high serum humane placental lactogen (hPL) levels.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	HPL ; Intermediate trophoblast ; Gestational trophoblastic disease ; Placental site trophoblastic tumor
Published in:	Pathologica, Vol. 115 Núm. 2 (april 2023) , p. 111-116, ISSN 1591-951X

DOI: 10.32074/1591-951X-873
PMID: 37114629

6 p, 538.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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