The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production
Badiola Benito, Nahuai (Institute for Research in Biomedicine (IRB Barcelona))
Alcalde Adell, Victor (Institute for Research in Biomedicine (IRB Barcelona))
Pujol, Albert (Anaxomics Biotech (Barcelona, Catalunya))
Münter, Lisa (Institut fuer Chemie und Biochemie. Freie Universitaet (Canadà))
Multhaup, Gerhard (Institut fuer Chemie und Biochemie. Freie Universitaet (Canadà))
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Coma, Mireia (Anaxomics Biotech (Barcelona, Catalunya))
Soler-Lopez, Montserrat (Institute for Research in Biomedicine (IRB Barcelona))
Aloy, Patrick 1972- (Institució Catalana de Recerca i Estudis Avançats)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2013
Abstract:	A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the effect of lansoprazole, and other proton-pump inhibitors (PPIs), on Aβ production in AD cellular and animal models. We found that lansoprazole enhances Aβ37, Aβ40 and Aβ42 production and lowers Aβ38 levels on amyloid cell models. Interestingly, acute lansoprazole treatment in wild type and AD transgenic mice promoted higher Aβ40 levels in brain, indicating that lansoprazole may also exacerbate Aβ production in vivo. Overall, our data presents for the first time that PPIs can affect amyloid metabolism, both in vitro and in vivo. © 2013 Badiola et al.
Grants:	Ministerio de Ciencia e Innovación PSE-010000-2009-1 Ministerio de Ciencia e Innovación BIO2010-22073
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 8 Núm. 3 (august 2013) , p. e58837, ISSN 1932-6203

DOI: 10.1371/journal.pone.0058837
PMID: 23520537

8 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles