Mechanisms of Modulation of Mitochondrial Architecture
Muñoz, Juan Pablo (Institut d'Investigació Biomèdica Sant Pau)
Basei, Fernanda Luisa (Universidade Estadual de Campinas)
Rojas, Maria Laura (Universidad Nacional de Córdoba (Argentina))
Galvis, David (Universidad CES (Colòmbia))
Zorzano Olarte, Antonio (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics proteins and the phospholipid composition of the mitochondrial membrane are key for fine-tuning the modulation of mitochondrial architecture. In addition, several factors including post-translational modifications such as the phosphorylation, acetylation, SUMOylation, and o-GlcNAcylation of mitochondrial dynamics proteins contribute to shaping the plasticity of this architecture. In this regard, several studies have evidenced that, upon metabolic stress, mitochondrial dynamics proteins are post-translationally modified, leading to the alteration of mitochondrial architecture. Interestingly, several proteins that sustain the mitochondrial lipid composition also modulate mitochondrial morphology and organelle communication. In this context, pharmacological studies have revealed that the modulation of mitochondrial shape and function emerges as a potential therapeutic strategy for metabolic diseases. Here, we review the factors that modulate mitochondrial architecture.
Grants:	Agencia Estatal de Investigación PID2019-106209RB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1015
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Lipids ; Membrane contact sites (MCSs) ; Metabolic disease ; Metabolism ; Mitochondria ; Mitochondrial dynamics ; Pharmacology ; Post-translational modification ; Tethers
Published in:	Biomolecules, Vol. 13 Núm. 8 (august 2023) , p. 1225, ISSN 2218-273X

DOI: 10.3390/biom13081225
PMID: 37627290

46 p, 2.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles