Neuropilin-1 as a Key Molecule for Renal Recovery in Lupus Nephritis : Insights from an NZB/W F1 Mouse Model
Sandoval, Sebastian (Vall d'Hebron Institut de Recerca (VHIR))
Solé Marcé, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Joseph-Mullol, Blanca (Vall d'Hebron Institut de Recerca (VHIR))
Royo, Maria (Vall d'Hebron Institut de Recerca (VHIR))
Moliné, Teresa (Hospital Universitari Vall d'Hebron)
Gabaldón, Alejandra (Hospital Universitari Vall d'Hebron)
Cortés Hernández, Josefina (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organs, with lupus nephritis (LN) occurring in 40-50% of SLE patients. Despite advances in diagnosis and treatment, LN remains a major cause of morbidity and mortality, with 10-20% of patients progressing to end-stage renal disease (ESRD). While knowledge of LN's pathogenesis has improved, mechanisms of renal recovery are still largely unexplored. Neuropilin-1 (NRP-1), a transmembrane receptor expressed in renal tissue, has emerged as a promising biomarker for assessing renal recovery in LN. This study evaluates and correlates longitudinal levels of NRP-1 with kidney histology using an NZB/W F1 mouse model of LN. A total of 30 mice were used, with 15 receiving intravenous cyclophosphamide (CYC) and 15 being untreated. NRP-1 levels were measured in urine and serum, and kidney samples were taken from a subgroup of mice for histological evaluation. The results demonstrated a progressive increase in renal and urinary NRP-1 expression, particularly notable at weeks 26 and 32. Urinary NRP-1 levels above 34. 40 ng/mL were strong predictors of favorable renal response, showing 100% sensitivity and 88% specificity. These findings indicate a robust correlation between urinary NRP-1 levels and renal histological recovery, underscoring the potential of NRP-1 as a valuable biomarker for assessing renal response in LN. This study demonstrates that renal production of NRP-1 is linked to histological recovery and establishes a foundation for future research into the role of NRP-1 in lupus kidney recovery.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Systemic lupus erythematosus (SLE) ; Lupus nephritis (LN) ; Neuropilin-1 (NRP-1) ; Biomarker ; Renal recovery
Publicat a:	International journal of molecular sciences, Vol. 25 (october 2024) , ISSN 1422-0067

DOI: 10.3390/ijms252111364
PMID: 39518917

13 p, 3.1 MB

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