Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain) : Implications for Prevention of Cervical Cancer
Stuardo Ávila, Valeria 1983- (Universidad de Chile)
Agustí, Cristina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Godinez, José Manuel (Red Temática de Investigación Coorporativa en Cáncer)
Montoliu, Alexandra (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Torne, Aureli (Hospital Clínic i Provincial de Barcelona)
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alcalde, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martín, Dolores (Hospital Universitari de Bellvitge)
Fernández-Montoli, Eulalia (Hospital Universitari de Bellvitge)
Vanrell, Cristina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Solé, Josefa (Hospital de Mataró. Consorci Sanitari del Maresme)
Canet, Yolanda (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Marqueta, José Manuel (Hospital de Palamós)
Mohamed, Jadiyettu (Hospital General de l'Hospitalet)
Cuenca, Isabel (Hospital Comarcal del Alt Penedès)
Lonca, Montserrat (Hospital Clínic i Provincial de Barcelona)
Sirera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ferrer, Elena (Hospital Universitari de Bellvitge)
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Lloveras, Belen (Hospital del Mar (Barcelona, Catalunya))
Miró, Josep (Hospital Clínic i Provincial de Barcelona)
de Sanjosé, Silvia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Casabona-Barbarà, Jordi (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Date:	2012
Abstract:	Background: High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods: We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results: Median age was 42 years. The prevalence of HR-HPV infection was 33. 2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3. 8%. The most common genotypes were 16(23%), 53(20. 3%), and 52(16. 2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2. 5; 95%confidence interval[CI],1. 1-5. 6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200cells/mm versus.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 7 Núm. 10 (30 2012) , p. e47755, ISSN 1932-6203

DOI: 10.1371/journal.pone.0047755
PMID: 23118894

9 p, 245.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles