First manifestation of cardiovascular disease according to age and sex in a Mediterranean country
Ortega, Emilio (Hospital Clínic i Provincial de Barcelona)
Genua, Idoia (Institut de Recerca Sant Pau)
Mata-Cases, Manel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Roqué, Mercè (Hospital Clínic i Provincial de Barcelona)
Vlacho, Bogdan (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Real, Jordi (Instituto de Salud Carlos III)
Franch-Nadal, Josep (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Mauricio Puente, Dídac (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Cardiovascular (CV) diseases are the most common cause of death worldwide. This study aimed to investigate the incidence and type of first CV event in a broad cohort of Spaniards, focusing on age and sex differences. This was a retrospective study using the SIDIAP database. Subjects aged 30-89 years in 2010 were included. Individuals with prevalent CV disease or atrial fibrillation were excluded. Subjects were followed until the occurrence of a CV event, death, or the study end (December 2016). CV outcomes (coronary heart disease [CHD], cerebrovascular or peripheral artery disease and heart failure [HF]) during follow-up were analyzed. Clinical, anthropometrical, and laboratory data were retrieved from clinical records. Overall, 3,769,563 at-risk individuals (51. 2 ± 15. 2 years) were followed for a median of 7 years. The cumulative incidence of a first CV event was 6. 66% (men vs. women, 7. 48% vs. 5. 90%), with the highest incidence (25. 97%) among individuals >75 years. HF (29%) and CHD (28. 8%) were the most common first events overall; in men it was CHD (33. 6%), while in women it was HF and cerebrovascular disease (37. 4% and 27. 4%). In younger age groups, CHD was more prevalent, with HF in older age groups. Baseline CV risks factors conferred more risk in younger ages and differed between men and women. The incidence and type of the first CV event in this Mediterranean region were significantly influenced by age and sex. This information is relevant for tailoring primary prevention strategies including the treatment of risk factors. Summary of methods and main findings of the present work.
Grants:	Ministerio de Economía y Competitividad CB15/00071 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00857
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiovascular events ; Epidemiology ; Risk factors ; Sex differences ; Age differences ; Large cohorts
Published in:	Frontiers in Cardiovascular Medicine, Vol. 11 (september 2024) , ISSN 2297-055X

DOI: 10.3389/fcvm.2024.1403363
PMID: 39355347

10 p, 2.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles