International External Validation of Risk Prediction Model of 90-Day Mortality after Gastrectomy for Cancer Using Machine Learning
Dal Cero, Mariagiulia (Institut Hospital del Mar d'Investigacions Mèdiques)
Gibert Fernandez, Joan (Institut Hospital del Mar d'Investigacions Mèdiques)
Grande, L (Institut Hospital del Mar d'Investigacions Mèdiques)
Gimeno, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Osorio, Javier (Hospital Clínic i Provincial de Barcelona)
Bencivenga, Maria (University of Verona)
Fumagalli Romario, Uberto (European Institute of Oncology, IRCCS)
Rosati, Riccardo (San Raffaele Hospital)
Morgagni, Paolo (GB Morgagni-L Pierantoni Surgical Department)
Gisbertz, Suzanne (Department of Surgery, University Medical Center, Amsterdam)
Polkowski, Wojciech P. (Medical University of Lublin)
Lara Santos, Lucio (Portuguese Institute of Oncology)
Kołodziejczyk, Piotr (Jagiellonian University)
Kielan, Wojciech (Wroclaw Medical University)
Reddavid, Rossella (University of Turin)
van Sandick, Johanna W. (Hospital Antoni van Leeuwenhoek)
Baiocchi, Gian Luca (Universitat de Brescia)
Gockel, Ines (Hospital Universitari de Leipzig)
Davies, Andrew (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Wijnhoven, Bas P. L. (Centre Mèdic Universitari Erasmus, Rotterdam)
Reim, Daniel (Universitat Tècnica de Munic)
Costa, Paulo (Universidade de Lisboa)
Allum, William H. (The Royal Marsden NHS Foundation Trust)
Piessen, Guillaume (University Lille)
Reynolds, John V. (Trinity College Dublin)
Mönig, Stefan P. (University Hospital of Geneva, Division of Abdominal Surgery)
Schneider, Paul M. (Center for Visceral, Thoracic and Specialized Tumor Surgery, Zurich)
Garsot Savall, Elisenda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Eizaguirre, Emma (Hospital de Donostia (Sant Sebastià, País Basc))
Miró, Mònica (Hospital Universitari de Bellvitge)
Castro, Sandra (Hospital Universitari Vall d'Hebron)
Miranda, Coro (Complejo Hospitalario de Navarra)
Monzonis-Hernández, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Pera Román, Manuel (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona. Departament de Cirurgia

Date:	2024
Abstract:	Background: Radical gastrectomy remains the main treatment for gastric cancer, despite its high mortality. A clinical predictive model of 90-day mortality (90DM) risk after gastric cancer surgery based on the Spanish EURECCA registry database was developed using a matching learning algorithm. We performed an external validation of this model based on data from an international multicenter cohort of patients. Methods: A cohort of patients from the European GASTRODATA database was selected. Demographic, clinical, and treatment variables in the original and validation cohorts were compared. The performance of the model was evaluated using the area under the curve (AUC) for a random forest model. Results: The validation cohort included 2546 patients from 24 European hospitals. The advanced clinical T- and N-category, neoadjuvant therapy, open procedures, total gastrectomy rates, and mean volume of the centers were significantly higher in the validation cohort. The 90DM rate was also higher in the validation cohort (5. 6%) vs. the original cohort (3. 7%). The AUC in the validation model was 0. 716. Conclusion: The externally validated model for predicting the 90DM risk in gastric cancer patients undergoing gastrectomy with curative intent continues to be as useful as the original model in clinical practice.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gastric cancer ; Gastrectomy ; Mortality ; Prediction ; Machine learning ; Validation
Published in:	Cancers, Vol. 16, Núm. 13 (July 2024) , ISSN 2072-6694

DOI: 10.3390/cancers16132463
PMID: 39001525

13 p, 987.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles