Ten tips on how to assess bone health in patients with chronic kidney disease
Jørgensen, Hanne S. (Katholieke Universiteit te Leuven (1970-))
Lloret, Maria Jesus (Institut de Recerca Sant Pau)
Lalayiannis, Alexander D. (Birmingham Women's and Children's Hospital (Regne Unit))
Shroff, Rukshana (UCL Great Ormond Street Hospital)
Evenepoel, Pieter (UZ Leuven)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Patients with chronic kidney disease (CKD) experience a several-fold increased risk of fracture. Despite the high incidence and the associated excess morbidity and premature mortality, bone fragility in CKD, or CKD-associated osteoporosis, remains a blind spot in nephrology with an immense treatment gap. Defining the bone phenotype is a prerequisite for the appropriate therapy of CKD-associated osteoporosis at the patient level. In the present review, we suggest 10 practical 'tips and tricks' for the assessment of bone health in patients with CKD. We describe the clinical, biochemical, and radiological evaluation of bone health, alongside the benefits and limitations of the available diagnostics. A bone biopsy, the gold standard for diagnosing renal bone disease, is invasive and not widely available; although useful in complex cases, we do not consider it an essential component of bone assessment in patients with CKD-associated osteoporosis. Furthermore, we advocate for the deployment of multidisciplinary expert teams at local, national, and potentially international level. Finally, we address the knowledge gaps in the diagnosis, particularly early detection, appropriate "real-time" monitoring of bone health in this highly vulnerable population, and emerging diagnostic tools, currently primarily used in research, that may be on the horizon of clinical practice.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bone density ; Chronic kidney disease ; Fracture ; Mineral and bone disorder ; Osteoporosis ; Renal osteodystrophy
Publicat a:	Clinical Kidney Journal, Vol. 17 Núm. 5 (january 2024) , p. sfae093, ISSN 2048-8513

DOI: 10.1093/ckj/sfae093
PMID: 38817914

19 p, 3.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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