Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations
Perez-Rando, Marta (Universitat de València)
García-Martí, Gracián (Quironsalud Hospital)
Escarti, María José (Hospital Clínic Universitari (València))
Salgado-Pineda, Pilar (FIDMAG Germanes Hospitalàries Research Foundation)
McKenna, Peter J. (FIDMAG Germanes Hospitalàries Research Foundation)
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation)
Grasa, Eva (Institut de Recerca Sant Pau)
Postiguillo, Alba (Instituto de Biomedicina de Valencia (IBV-CSIC))
Corripio, Iluminada (Consorci Hospitalari de Vic)
Nacher, Juan (Instituto de Biomedicina de Valencia (IBV-CSIC))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Different lines of evidence indicate that the structure and physiology of the basal ganglia and the thalamus is disturbed in schizophrenia. However, it is unknown whether the volume and shape of these subcortical structures are affected in schizophrenia with auditory hallucinations (AH), a core positive symptom of the disorder. We took structural MRI from 63 patients with schizophrenia, including 36 patients with AH and 27 patients who had never experienced AH (NAH), and 51 matched healthy controls. We extracted volumes for the left and right thalamus, globus pallidus, putamen, caudate and nucleus accumbens. Shape analysis was also carried out. When comparing to controls, the volume of the right globus pallidus, thalamus, and putamen, was only affected in AH patients. The volume of the left putamen was also increased in individuals with AH, whereas the left globus pallidus was affected in both groups of patients. The shapes of right and left putamen and thalamus were also affected in both groups. The shape of the left globus pallidus was only altered in patients lacking AH, both in comparison to controls and to cases with AH. Lastly, the general PANSS subscale was correlated with the volume of the right thalamus, and the right and left putamen, in patients with AH. We have found volume and shape alterations of many basal ganglia and thalamus in patients with and without AH, suggesting in some cases a possible relationship between this positive symptom and these morphometric alterations.
Ajuts:	Agencia Estatal de Investigación PID2021-127595OB-I00
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Auditory hallucinations ; Schizophrenia ; Shape analysis ; Subcortical ; Volume analysis
Publicat a:	Progress in neuro-psychopharmacology & biological psychiatry, Vol. 131 (20 2024) , p. 110960, ISSN 1878-4216

DOI: 10.1016/j.pnpbp.2024.110960
PMID: 38325744

10 p, 1.7 MB

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