Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock : Why Is It Still a Male World?
Perna, Benedetta (University Hospital of Ferrara)
Raparelli, Valeria (Università degli Studi di Roma "La Sapienza")
Tordo Caprioli, Federica (University Hospital of Ferrara)
Blanaru, Oana Teodora (University Hospital of Ferrara)
Malacarne, Cecilia (University Hospital of Ferrara)
Crosetti, Cecilia (University Hospital of Ferrara)
Portoraro, Andrea (University Hospital of Ferrara)
Zanotto, Andrea (University Hospital of Ferrara)
Strocchi, Francesco Maria (University Hospital of Ferrara)
Rapino, Alessandro (University Hospital of Ferrara)
Costanzini, Anna (University Hospital of Ferrara)
Maritati, Martina (University of Ferrara)
Lazzari, Roberto (Institut de Recerca Sant Pau)
Spampinato, Michele Domenico (University Hospital of Ferrara)
Contini, Carlo (University of Ferrara)
De Giorgio, Roberto (University Hospital of Ferrara)
Guarino, Matteo (University Hospital of Ferrara)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43. 2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gender ; Norepinephrine ; Precision medicine ; Septic shock ; Sex ; Vasoactive agents
Published in:	Microorganisms, Vol. 12 Núm. 4 (april 2024) , p. 821, ISSN 2076-2607

DOI: 10.3390/microorganisms12040821
PMID: 38674765

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