Genomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica)
Ráez-Bravo, Arián (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Granados Torres, José Enrique (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Espinosa, José (Universidad de León)
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques)
Serrano Ferron, Emmanuel (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Puigdecanet, Eulàlia (Institut Hospital del Mar d'Investigacions Mèdiques)
Bódalo, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Pérez Jiménez, Jesús María (Universidad de Jaén)
Soriguer, Ramón C (Estación Biológica de Doñana)
Cano-Manuel, Francisco Javier (Espacio Natural Sierra Nevada)
Fandos, Paulino
López Olvera, Jorge R (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2024
Abstract:	Background: Sarcoptic mange is an emerging and neglected contagious skin disease caused by the mite Sarcoptes scabiei, affecting humans, domestic animals, and wildlife. Mange is the main disease and a major concern for the management and conservation of populations of Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate endemic to the Iberian Peninsula and Northern Pyrenees. Differences in host-parasite interaction and host immune response determine mange clinical outcome, but little is known about the related differences in gene expression. This study determined blood and skin gene expressions in S. scabiei-experimentally infested Iberian ibexes. Results: Infestation with S. scabiei promoted immune and inflammatory genomic responses both in skin and blood, with two different clinical outcomes: either severe infestation or recovery. Sarcoptes scabiei induced local skin immunosuppression to favour its multiplication and establishment of the infestation in the host. Skin gene expression was mostly inflammatory and inefficient to control mange in the severely infected ibexes. Conversely, the immune skin response of the recovered ibexes effectively recognised S. scabiei and activated T-cells, limiting the infestation. Consequently, inflammation-related genes were more expressed in the blood of the severely infested ibexes than in those that recovered. Conclusions: The results demonstrate that skin local cellular immune response is key to control sarcoptic mange and prevent the systemic spread of the disease and the associated inflammatory response. These results will be useful to understand the pathogenesis and drivers of the differential outcome of mange at individual scale, and the population and ecological consequences of such variability in Iberian ibex, as well as in other wildlife species, domestic animals, and humans.
Grants:	Ministerio de Economía y Competitividad CGL2012-40043-C02-01 Ministerio de Economía y Competitividad CGL2012-40043-CO2-02 Ministerio de Economía y Competitividad CGL2016-80543-P
Note:	Altres ajuts: the research activities of JEG, JMP, RCS, FJCM and PF were partially funded by the Andalusian Government, PAIDI: RNM-118 group
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Animals ; Goats parasitology ; Genomic response ; Scabies ; Skin parasitology ; Sarcoptes scabiei ; Gene set enrichment analysis ; Host-parasite interactions ; Goat diseases ; Gene expression ; Microarray
Published in:	BMC genomics, Vol. 25 Núm. 1 (2024) , p. 1144, ISSN 1471-2164

DOI: 10.1186/s12864-024-10999-4
PMID: 39604877

14 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Research group Wildlife Ecology & Health
Articles > Research articles
Articles > Published articles